Brain MRI in Stroke Patients With Intracardiac Thrombus

Brain MRI Characteristics in Stroke Patients With Intracardiac Thrombus

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04456309

Acronym

BRAIN IRM

Enrollment

122

Registered

2020-07-02

Start date

2020-05-01

Completion date

2020-12-31

Last updated

2025-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intracardiac Thrombus, Stroke

Keywords

brain MRI

Brief summary

Acute infarction patterns have been described in cardioembolic stroke, mainly with atrial fibrillation (AF) or patent foramen ovale. We aimed to analyse acute infarction MRI characteristics in stroke patients with intracardiac thrombus (ICT) compared with stroke patients with AF.

Interventions

OTHERNo intervention,

pure observational study

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* consecutive patients presenting with acute symptomatic cardioembolic infarction associated with ICT, recruited and registered in the stroke database between June 2018 and November 2019 of our centre (Nîmes University Hospital, France). These patients were compared with consecutive cardioembolic stroke patients with known or newly discovered AF (in the absence of ICT on echocardiography), recruited during the same time period. * Brain MRI (including diffusion-weighted imaging \[DWI\]) performed within one week of symptom onset; complete etiological work-up including intracranial (time-of-flight \[TOF\], gadolinium-enhanced magnetic resonance angiography \[MRA\], or computed tomographic angiography \[CTA\]) and extracranial (gadolinium-enhanced MRA, CTA, or duplex ultrasound) vessel imaging; transthoracic or transoesophageal echocardiography; and ≥24h ECG monitoring (acute stroke unit monitoring and/or Holter ECG monitoring).

Exclusion criteria

* opt-out patient

Design outcomes

Primary

Measure	Time frame	Description
Brain MRI characteristics	Day of inclusion (Day 1)	infarction location (anterior/middle/posterior cerebral artery territory; anterior/posterior/mixed anterior-posterior circulation; multiterritorial infarction; brainstem; cerebellum; small cortical cerebellar infarctions \[SCCI\] or non-SCCI; cortical/subcortical/corticosubcortical)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 16, 2026