COVID, SARS-CoV2
Conditions
Brief summary
Approximately 15% of patients with SARS-CoV-2 infection / COVID-19 develop a severe clinical course. This leads to hospitalization and potentially life threatening complications such as pneumonia and respiratory failure. Predictors for early detection and risk stratification are urgently needed. Moreover, only scarce information is available for long-term follow-up and late complications associated with infection. We therefore aimed to find predictors for severe courses of the novel disease as well as to establish strategies for therapeutic monitoring and follow-up.
Interventions
None listed
Sponsors
Heidelberg University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* SARS-CoV-2 infection / COVID 19
Exclusion criteria
* invasive ventilation * respiratory failure at admission
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| TLCO | 3-5 days intervals (inpatients) | Transfer factor for carbon monoxide |
| D5-20 | 3-5 days intervals (inpatients | frequency dependence of resistance as measured by oscillometry |
| FEV1/FVC | 3-5 days intervals (inpatients) | forced expiratory volume in 1 s / forced vital capacity (as measured by spirometry) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| comorbidities | at hospital admission and each follow (every 1-6 months) | structured questionnaire |
| clinical symptoms | 3-5 days intervals (inpatients), 1-6 months (outpatients, follow up) | structured qualitative questionnaire |
| St. George's Respiratory Questionnaire total score | 3-5 days intervals (inpatients), 1-6 months (outpatients, follow up) | validated questionnaire (scores range from 0 to 100, with higher scores indicating more limitations) |
Countries
Germany
Contacts
Primary ContactFrederik Trinkmann, MD
Outcome results
None listed