Chilblains, COVID-19
Conditions
Brief summary
Chilblains (inflammatory lesion of the feet or hands) have been reported with an unusual frequency during the confinement period, most commonly in children, teenagers and young adults. The aim of the ECCES study is to find out whether these manifestations of chilblains can be linked to the SARS-CoV-2 coronavirus. For this, an epidemiologic study will compare two types of family (or more precisely people who were confined together in March-April-May): * case family in which at least one of the members had chilblains * comparator family in which none of the members had chilblains Environment (home lockdown) of the two types of family will be analyzed. Each member of the family will be suggested doing a serological test.
Interventions
OTHERBiological sample collection
10mL blood sample
Sponsors
Rennes University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* case family * at least one of the members with chilblains * diagnosis of chilblains (anamnesis and pictures) written informed consent * comparator family * none of the members with chilblains * one member matched on age (+/- 1 year) to a patient with chilblains * written informed consent
Exclusion criteria
\- Subject legally protected (under judicial protection, guardianship), persons deprived of liberty
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of viral exposure in case family compared to comparator family | Through study completion, an average of 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of seropositivity rates in subjects with chilblains and their age-matched controls | Through study completion, an average of 3 months |
| Comparison of SARS-CoV-2 seropositivity rates among members of case (subject with chilblains) and control (subject without chilblains) outbreaks | Through study completion, an average of 3 months |
| Antibody avidity and differentiated IgG and IgM assay by subject in the homes | Through study completion, an average of 3 months |
Countries
France
Outcome results
None listed