Endoplasmic Reticulum Stress, Recurrent Pregnancy Loss
Conditions
Brief summary
To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured. It is aimed to show the effect of endoplasmic reticulum stress on recurrent pregnancy loss.
Interventions
OTHERx box binding protein
Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.
Sponsors
Kanuni Sultan Suleyman Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* with three or more miscarriages before 20 th week of gestation * had no chronic or acute inflammatory disease * used no steroids, anti-inflammatory, or antioxidant medications
Exclusion criteria
* had inflammatory diseases * had systemic disease * Anatomical abnormalities, infectious, endocrine, or genetic etiologies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Show the effect of endoplasmic reticulum stress on recurrent pregnancy loss | 3 months | Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured. |
Countries
Turkey (Türkiye)
Outcome results
None listed