Dyskinesias, Parkinson Disease
Conditions
Keywords
Parkinson disease, Dyskinesia, follow up
Brief summary
Parkinson' patients who have not had dyskinesia would be observed for 2 years in a multicenter prospective study with the purposes to clarify the predicting factors of dyskinesia.
Detailed description
Parkinson' patients with daily levodopa dosage above 200mg and no dyskinesia would be recruited into the study. They would be observed for two years for analyzed the predicting factors of dyskinesia. At the baseline, demographic information, Clinical information, blood sample, picture of tongure coating would be collected at the baseline. All participants were evaluated every three months for two years. The severity of motor symptoms were evaluated every 6 months.
Interventions
None listed
Sponsors
Shanghai Municipal Hospital of Traditional Chinese Medicine
Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
Second Affiliated Hospital of Soochow University
The Affiliated BenQ Hospital of Nanjing Medical University
The Affiliated Hospital of Qingdao University
The First Affiliated Hospital with Nanjing Medical University
Zhejiang Provincial Tongde Hospital
Shaoxing Hospital of Traditional Chinese medicine
The First People Hospital of Hangzhou Lin An District
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
\- 1) Patients have been clinically diagnosed with Parkinson disease at the recruitment. 2\) Patients have received Levodopa treatment with the daily dosage above 200mg.
Exclusion criteria
* 1\) be suspicious of atypical Parkinson or other Parkinson syndrome. 2) have experienced dyskinesia. 3) incorporation to the investigation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the occurrence of dyskinesia and its related predicting factors | The data would be analyzed within 9 months of the study completion. The outcome would be reported within 1 year of the the study completion. | to evaluate the occurrence of dyskinesia during the 2 years of follow-up and identify its predicting factors of dyskinesia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| to evaluate patients ' living quality and the severity of non motor symptoms during the 2 years of follow-up | The data would be analyzed within 9 months of the study completion. The outcome would be reported within 1 year of the the study completion. | to evaluate patients ' living quality and the severity of non motor symptoms during the 2 years of follow-up |
Countries
China
Outcome results
None listed