Hormonal and Metabolic Aspects of Endoscopic Sleeve Gastroplasty

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04452786

Enrollment

Registered

2020-06-30

Start date

2020-06-05

Completion date

2023-04-30

Last updated

2021-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endoscopic Sleeve Gastroplasty, Glucose Metabolism Disorders, Gut Hormones, Laparoscopic Sleeve Gastrectomy

Brief summary

The investigators of the study want to investigate the complex interactions between glucose metabolism, food intake/weight loss, and different appetite regulating hormones after ESG in comparison with conventional laparoscopic sleeve gastrectomy (LSG).

Interventions

PROCEDUREEndoscopic sleeve gastroplasty

Four-hour solid mixed meal test

PROCEDURELaparoscopic sleeve gastrectomy

Four-hour solid mixed meal test

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Age \> 18 years * Scheduled for endoscopic or laparoscopic sleeve at Hvidovre Hospital * HbA1c \< 48 mmol/mol before surgery, and no history of diabetes * HbA1c \< 48 mmol/mol and fasting plasma glucose \< 6.1 mmol/l at inclusion * BMI\<45

Exclusion criteria

* Hemoglobin \< 6.5 mmol/l at inclusion * Pregnancy or breast feeding * Medication affecting the planned examinations

Design outcomes

Primary

Measure	Time frame	Description
Changes in ghrelin (pg/ml)	240 minutes	Changes in ghrelin after a solid meal test compared before and after surgery

Secondary

Measure	Time frame
Changes in gut hormone response before and after sugery (pmol/L)	240 minutes

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026