Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome

Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome: Study Conducted in the Hauts-de-France

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04452266

Acronym

PrediLynch

Enrollment

150

Registered

2020-06-30

Start date

2020-08-14

Completion date

2020-10-20

Last updated

2021-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lynch Syndrome

Keywords

lynch syndrome, endometrial cancer

Brief summary

Lynch Syndrome increases Endometrial Cancer Occurrence in women due to failure in MisMatch Repair System. Lifetime Cumulative risk of developing endometrial Cancer is approximatively 40% in women with Lynch Syndrome. Endometrial cancer is the third women cancer in France. Many risk factors are known in general population. Lots of factors are related to over exposure to estrogen. Data about influence of general risk factors in Women with Lynch Syndrome are poor. Recently, a cohort study appears to have shown a significant decrease in the risk of endometrial cancer with multiparity, the use of hormonal contraception and late menopause in Lynch women. The impact of weight and certain metabolic parameters on the occurrence of endometrial cancers remains poorly known to this day.

Interventions

OTHERquestionnaire assesment

Each patient will to answer questions about their medical history.

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

30 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Lynch Syndrome Diagnosis at University Hospital * Alive at study time * Age over 30 at endometrial cancer or Lynch Syndrome Diagnosis Case group : \- No cancer before endometrial cancer diagnosis Control group : * No endometrial cancer developped * Free cancer women at Lynch Syndrome diagnosis

Exclusion criteria

* Refusing to participate * Poor understanding of the French language * Other cancer diagnosed before endometrial cancer * Hysterectomy before lynch diagnosis for free cancer women

Design outcomes

Primary

Measure	Time frame	Description
Correlation between endometrial cancer and predictif factors	Baseline	Endometrial cancer (yes/no) and explicative variable: Diabetes before endometrial cancer or Lynch syndrome diagnosis; Smoking ; Maximal Weight ; Age at menarche; Parity ; Age at first birth ; Contraceptive use.

Secondary

Measure	Time frame	Description
Correlation between endometrial cancer and predictif factors in post menopausal woman	Baseline	Endometrial cancer (yes/no) and explicative variable: Menopause age; Hormonal menopause treatment

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026