Vibrio Infections
Conditions
Brief summary
The purpose of this study is to identify the epidemiological and clinical characteristics of patients diagnosed with non-cholera Vibrio infection in Western France from 2000 to 2019.
Detailed description
Vibrios are gram-negative, ubiquitous bacteria of the marine flora and are found particularly in warm waters. For example, the incidence is high in Florida and Vibrio infections are now reportable in the United States. Different species of Vibrio are described. A distinction is made between choleric vibrios belonging to serogroups O1 and O139, responsible for cholera epidemics, and non-choleric vibrios. Our study will focus on non-cholera vibrios. Vibrio infections can occur by eating contaminated raw seafood or by exposure of a wound to the marine environment. They occur mainly during the hot summer months. This can be explained on the one hand by higher water temperature and on the other hand by increased beach use. With global warming, it is possible that Vibrio infections may increase in number and location.
Interventions
OTHERnon-cholera Vibrio infection
Epidemiology of patients diagnosed with non-cholera Vibrio infection
Sponsors
Groupe Hospitalier de la Rochelle Ré Aunis
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* non-cholera Vibrio infection
Exclusion criteria
* vibriosis to Vibrio cholerae O1 and O139
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection | Up to 20 years, from 2000-2019 | A non-cholerae or non-O1/O139 Vibrio infection was defined by a biological sample (blood, superficial sample, deep sample, and ear sample) positive to a Vibrio species other than Vibrio cholerae O1-O139. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants Associated With Environmental Factors | at inclusion | environmental factors : seafood consumption, bathing/water activity, Injury in the aquatic environment, Walk to the beach, Handling of seafood products, returning from a trip abroad |
| Number of Participants Per Identified Species | at inclusion | Species: Vibrio alginolyticus, Vibrio cholerae Non-O1/Non-O139 Non toxinogenic, Vibrio parahaemolyticus, Vibrio vulnificus, Vibrio sp or other |
| Number of Patients Per Clinical History | at inclusion | Clinical history: diabetes, heart failure, hepatopathy, neoplasia, alcohol use disorder, Immunosuppressive drug, Pre-existing wound, Digestive surgery, Hemopathy, Kidney Disease |
| Number of Participants Treated by Antibiotics | through study completion, an average of 1 month | — |
| Number of Participants Per Outcome | through study completion, an average of 1 month | outcome :cure, cure with amputation, and deceased due to the infection |
| Number of Participants by Month of the Years | at inclusion | — |
Countries
France
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Non-cholera Vibrio Infection Patients diagnosed with non-cholera Vibrio infection in Western France from 2000 to 2019
non-cholera Vibrio infection: Epidemiology of patients diagnosed with non-cholera Vibrio infection | 67 |
| Total | 67 |
Baseline characteristics
| Characteristic | Non-cholera Vibrio Infection |
|---|---|
| Age, Categorical <=18 years | 11 Participants |
| Age, Categorical >=65 years | 28 Participants |
| Age, Categorical Between 18 and 65 years | 28 Participants |
| Age, Continuous | 54.4 years STANDARD_DEVIATION 24.2 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 0 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 0 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 67 Participants |
| Region of Enrollment France | 67 participants |
| Sex: Female, Male Female | 13 Participants |
| Sex: Female, Male Male | 54 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 8 / 67 |
| other Total, other adverse events | 41 / 67 |
| serious Total, serious adverse events | 35 / 67 |
Outcome results
Primary
Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection
A non-cholerae or non-O1/O139 Vibrio infection was defined by a biological sample (blood, superficial sample, deep sample, and ear sample) positive to a Vibrio species other than Vibrio cholerae O1-O139.
Time frame: Up to 20 years, from 2000-2019
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection | Center 1 | 20 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection | Center 2 | 7 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection | Center 3 | 2 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection | Center 4 | 18 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection | Center 5 | 10 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection | Center 6 | 1 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection | Center 7 | 1 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection | Center 8 | 8 Participants |
Secondary
Number of Participants Associated With Environmental Factors
environmental factors : seafood consumption, bathing/water activity, Injury in the aquatic environment, Walk to the beach, Handling of seafood products, returning from a trip abroad
Time frame: at inclusion
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Associated With Environmental Factors | Bathing in the sea | 12 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Associated With Environmental Factors | Injury in the aquatic environment | 5 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Associated With Environmental Factors | Aquatic activities | 3 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Associated With Environmental Factors | Walk on the beach | 2 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Associated With Environmental Factors | Seafood consumption | 7 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Associated With Environmental Factors | Handling of seafood products | 7 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Associated With Environmental Factors | Returning from a trip abroad | 2 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Associated With Environmental Factors | Unknown | 29 Participants |
Secondary
Number of Participants by Month of the Years
Time frame: at inclusion
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | January | 0 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | February | 0 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | March | 1 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | April | 0 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | May | 1 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | June | 6 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | July | 14 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | August | 19 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | September | 11 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | October | 6 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | Novermber | 2 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | December | 1 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants by Month of the Years | Unknown | 6 Participants |
Secondary
Number of Participants Per Identified Species
Species: Vibrio alginolyticus, Vibrio cholerae Non-O1/Non-O139 Non toxinogenic, Vibrio parahaemolyticus, Vibrio vulnificus, Vibrio sp or other
Time frame: at inclusion
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Per Identified Species | Vibrio alginolyticus | 23 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Per Identified Species | Vibrio parahaemolyticus | 20 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Per Identified Species | Non-O1/O139 Vibrio cholerae | 10 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Per Identified Species | Vibrio vulnificus | 7 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Per Identified Species | Vibrio spp | 7 Participants |
Secondary
Number of Participants Per Outcome
outcome :cure, cure with amputation, and deceased due to the infection
Time frame: through study completion, an average of 1 month
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Per Outcome | Cured | 53 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Per Outcome | Amputation | 6 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Per Outcome | Infection related death | 8 Participants |
Secondary
Number of Participants Treated by Antibiotics
Time frame: through study completion, an average of 1 month
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Treated by Antibiotics | Treated by antibiotics | 53 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Treated by Antibiotics | Did not received antibiotics | 5 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Participants Treated by Antibiotics | unknown | 9 Participants |
Secondary
Number of Patients Per Clinical History
Clinical history: diabetes, heart failure, hepatopathy, neoplasia, alcohol use disorder, Immunosuppressive drug, Pre-existing wound, Digestive surgery, Hemopathy, Kidney Disease
Time frame: at inclusion
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Patients Per Clinical History | Heart failure | 24 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Patients Per Clinical History | Neoplasia | 11 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Patients Per Clinical History | Diabetes | 8 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Patients Per Clinical History | kidney failure | 7 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Patients Per Clinical History | Immune disease | 7 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Patients Per Clinical History | Haemopathy | 5 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Patients Per Clinical History | Liver disease | 5 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Patients Per Clinical History | Alcohol use disorder | 7 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Patients Per Clinical History | Pre-existing wound | 6 Participants |
| Non-cholerae or Non-O1/O139 Vibrio Infection | Number of Patients Per Clinical History | Digestive surgery | 6 Participants |