Cystic Fibrosis
Conditions
Brief summary
CF is a complex, inherited illness that can affect many organs of the body. The investigators have found that some patients with CF have reported more problems with memory than would be expected at their age and that patients appear to be using memory strategies to overcome memory loss. The investigators intend to objectively test memory and examine MRI images of the brain of patients with CF.
Detailed description
Patients with CF have several potential risk factors which may predispose them to memory problems. Because the CF population has historically only been young, this is not something that has been focused on. No research has currently identified whether patients with CF have a much earlier risk of developing cognitive impairment or how CF impacts on the brain. There has not previously been work in this area of CF and the investigators are in a unique position with the Cardiff University Brain Research Imaging Centre (CUBRIC) and its expertise to be able to perform Magnetic Resonance Imagining (MRI) scans and neurocognitive testing on patients with CF for the first time.
Interventions
DIAGNOSTIC_TESTMRI head
MRI head
Sponsors
Cardiff University
Cardiff and Vale University Health Board
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or Female, aged greater or equal to 30 years * A diagnosis of CF * Primary school education or above * Able to provide informed consent
Exclusion criteria
* Contraindications to MRI as found on the CUBRIC screening form (including presence of indwelling metal devices/clips) * Existing neurological disease affecting cognition (including stroke and traumatic brain injury) * Existing diagnosis of dementia documented in medical notes * Vascular complications of diabetes * Requiring supplemental oxygen -long term or overnight * Hepatic failure * Overt psychiatric disorders * Past or present alcohol or recreational drug misuse * Pregnancy * Current infection Smoker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective memory scores | up to one year |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MRI head | up to one year | the investigators will acquire structural and functional MRI data at 3T to explore brain health of CF patients compared to control data. Structural MRI will include T1 and T2 weighted anatomical images for group comparisons of brain morphology (volume, cortical thickness). T1 weighted images will also be used as reference images for all other MRI parameters. |
Countries
United Kingdom
Outcome results
None listed