Metabolic Syndrome, Obesity, Childhood
Conditions
Brief summary
Pediatric obesity is a risk factor for the onset of obesity in adulthood and is a risk factor for various chronic non-communicable diseases. Metabolic syndrome (MS) is the name for a group of risk factors that increase cardiovascular risk and other health problems characterized by the presence of abdominal obesity, dyslipidemia, hyperglycaemia and high blood pressure. Numerous preclinical and clinical data suggest a potential role of the intestinal microbiota in these diseaes. Unfortunately, comparative studies of the gut microbiota are still scarce in pediatric subjects suffering from obesity than obesity complicated by MS. The aim is to study the metagenomics and metabolomics characteristics of the intestinal microbiota in obese children/adolescents with or without MS, that could provide useful data for innovative intervention strategies for these conditions.
Interventions
OTHERObese with or without metabolic syndromesubjects
Children with obesity and with or without metabolic syndrome
Sponsors
Federico II University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
10 Years to 16 Years
Inclusion criteria
* Subjects aged between 10-16 years, * diagnosis of obesity or obesity complicated by metabolic syndrome * healthy controls
Exclusion criteria
* Age at enrollment \< 10 or \>16 years, * concomitant presence of chronic diseases, * neoplasms, * immunodeficiencies, * chronic infections, * autoimmune diseases, * chronic inflammatory bowel diseases, * celiac disease, -genetic-metabolic diseases, - * cystic fibrosis * chronic lung diseases, * malformations of the cardiovascular/respiratory/gastrointestinal system, * neuropsychiatric disorders * neurological pathologies, * assumption of antibiotics and/or pre/pro/synbiotics * onset of diarrhea or acute gastrointestinal disease during the 12 weeks prior to enrollment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of metagenomic characteristics of the intestinal microbiota in subjects with obesity, obesity complicated by metabolic syndrome and healthy controls | at enrollment | Evaluation of gut microbiota composition |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of metabolomic characteristics of the intestinal microbiota in subjects with obesity, obesity complicated by metabolic syndrome and healthy controls | at enrollment | Evaluation of butyrate |
| Concentration of the metabolomic characteristics of the intestinal microbiota in subjects with obesity, obesity complicated by metabolic syndrome and healthy controls | at enrollment | Evaluation of acetate |
Countries
Italy
Outcome results
None listed