Observational Database on Deep Brain Stimulation in Tourette Syndrome

Pre et Post-operative Evaluation of Patients With Tourette Syndrome Treated With High Frequency Bilateral Stimulation of the Anterior Part of the Internal Pallid Globus

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04449068

Acronym

POSTSTIC

Enrollment

Registered

2020-06-26

Start date

2021-01-12

Completion date

2036-06-12

Last updated

2026-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tourette Syndrome

Keywords

bilateral deep brain stimulation, Tourette syndrome,

Brief summary

Within an ongoing deep brain stimulation (DBS) program for Tourette syndrome (TS) at the Department of Neurology, Pitié-Salpêtrière Hospital, Paris/France, the investigator team plans to evaluate patients pre-operatively and then at one year intervals post-operatively until the 5-year mark has been achieved. The investigator team will investigate tic severity, psychiatric co-morbidities, quality of life, and neuropsychological measures.

Detailed description

Since the completion of the STIC trial in 2017, the french team continues to offer DBS of the globus pallidus internus (GPi) to selected, treatment-refractory patients with TS. On average, three to four patients undergo surgery every year. Even though a first follow-up of the STIC cohort up to four years post-op indicates ongoing improvement of tic severity, many questions remains regarding the efficacy of GPi DBS in TS. These questions include frequent comorbidities of TS, quality of life, evolution of medication and stimulation parameters, as well as neuropsychological functioning. Therefore, the investigator proposes to evaluate all patients undergoing GPi DBS for TS to be evaluated comprehensively pre-operatively and once yearly after surgery until reaching the 5-year mark. The investigator team hopes these data may help to plan for future international multicenter trials, and provide indications on prognostic factors concerning response to GPi DBS in TS.

Interventions

OTHERNeurological and neuropsychological Follow-up after deep brain stimulation

Investigation of tic severity, psychiatric co-morbidities, quality of life, and neuropsychologcial measures until the 5-year after deep brain stimulation (DBS)

DEVICEEEG recordings

EEG recordings at 2 visits (V1 and V2)

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

15 Years to No maximum

Healthy volunteers

Inclusion criteria

* Tourette syndrome severe and drug-resistant eligible for bilateral deep brain stimulation * Person who voluntarily and knowledgeably agreed to participate in the study

Exclusion criteria

* Non affiliation to a French social security system (recipient or assign) excluding AME

Design outcomes

Primary

Measure	Time frame	Description
Measure the severity of tics	Month 60	Measure the severity of tics, determined by the YGTSS-R (Yale Global Tic Severity Scale score - revised) . The overall score is between 0 (no TICS) and 100 (severity in TICS) therefore a score decrease is expected .

Countries

France

Contacts

CONTACTAndreas HARTMANN, MD

andreas.hartmann@aphp.fr1 42 16 13 16

CONTACTYulia Worbe, MD,PHD

yulia.worbe@aphp.fr142161316

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 7, 2026