Pancreas; Fistula
Conditions
Brief summary
This study investigated the impact of highest drain fluid amylase (DFA) level on postoperative pancreatic fistula (POPF) severity and outcomes of patients undergoing pancreaticoduodenectomy (PD) with POPF. Patient demographics of biochemical POPF and clinically relevant POPF (CR-POPF) were compared. Predictive factors were assessed using binary logistic regression. Receiver operating characteristic curve analysis was performed to determine the optimal cutoff value of highest DFA (beyond 3 days post-PD). The investigators compared length of hospital stay, surgical mortality rates, and need for postoperative interventions by highest DFA level.
Interventions
None listed
Sponsors
Chang Gung Memorial Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Inclusion criteria
* underwent PD from October 2010 to September 2018 in our institution
Exclusion criteria
* younger than 20 years of age * clinical information was unavailable due to private or legal issues * receiving PD without pancreaticojejunostomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative pancreatic fistula | through study completion, an average of 2 month | fluid output of any measureable volume via an operatively placed drain with amylase activity greater than 3 times the upper normal serum value |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postoperative interventions | through study completion, an average of 2 month | transarterial embolization, image-guided second drainage, and reoperation |
| length of hospital stay | through study completion, an average of 2 month | — |
| 30-day mortality rates | 30 day | — |
Outcome results
None listed