Mechanical Ventilation Complication
Conditions
Brief summary
Prospective observational trial in patients admitted to ICU diagnosed with COVID-19 requiring invasive mechanical ventilation. Characterization of Reverse Triggering asynchrony during the first 5 days of invasive mechanical ventilation and other asynchronies, and its correlation with different outcomes.
Interventions
DIAGNOSTIC_TESTAsynchronies detection
Asycnhronies detection
Sponsors
Corporacion Parc Tauli
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients under invasive mechanical ventilation more than 24 hours and with a minimum of 48 hours of respiratory signals registered from the ventilator * Diagnosis of COVID-19
Exclusion criteria
* less than 48 hours of data, * age \< 18 years * admitted from other centers under invasive mechanical ventilation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence and pattern of presentation of Reverse triggering in COVID-19 patients under invasive mechanical ventilation | during the 5 first days of invasive mechanical ventilation | To analyze the incidence of Reverse Triggering in the initial phases of invasive mechanical ventilation in COVID-19 patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Reverse Triggering related to the level of sedation in COVID-19 patients under invasive mechanical ventilation | From the day of mechanical ventilation initation up to 5 days or the last day of mechanical ventilation | To correlate the presence of Reverse Triggering with the level of sedation and use of neuromuscular blockers |
| Reverse triggering and secondary asynchronies in COVID-19 patients under invasive mechanical ventilation | From the day of mechanical ventilation initiation up to 5 days | To analyze the incidence of breath stacking and ineffective efforts secondary to RT. |
| Incidence and pattern of presentation of asynchronies in COVID-19 patients under invasive mechanical ventilation | Each day from the day of mechanical ventilation initiation until the day of mechanical ventilation withdrawal or up to 28 days | To analyze the incidence of RT, ineffective efforts and double triggering throughout the period of invasive mechanical ventilation |
| Influence of asynchronies in different outcomes in in COVID-19 patients under invasive mechanical ventilation | Each day from the day of mechanical ventilation initiation until the end of invasive mechanical ventilation, ICU discharge and hospital discharge or up to 28 days | To correlate the presence of asycnhronies and its type with duration of invasive mechanical ventilation, ICU length of stay and survival |
Countries
Spain
Outcome results
None listed