Ghrelin
Conditions
Brief summary
This study aimed to explore the effects of a 12-week combined exercise on ghrelin O acyl transferase, acylated ghrelin and desacylated ghrelin levels in obese girls.
Detailed description
Little is known about on ghrelin O acyl transferase (GOAT), acylated ghrelin (AG) and desacylated ghrelin (DAG) levels during long-term exercise in adolescent population. Our previous study showed that combined exercise program in overweight children increases DAG with unchanged AG. This study aimed to explore the effects of a 12-week combined exercise on GOAT, AG, and DAG in obese girls.
Interventions
Combined exercise programme, consisting of warm-up, aerobic exercise, resistance training, and cool-down, 3 days a week after school for 50 minutes from 17;30 under supervision by a trainer plus 300 kcal deficit diet
OTHERControl
300 kcal deficit diet only
Sponsors
Pusan National University Yangsan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
16 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* girls between 16 and 18 years * being classified as being overweight or obese defined with the 85th percentile of body mass index or above based on the 2007 growth chart for Korean children aged 2-18 years. * After consultation with a physician, they were required to be considered physically healthy enough to engage in regular exercise after school.
Exclusion criteria
* participation in any weight-management programme in the past 6 months * engagement in other exercise programs except for regular physical education at school * smoking * amenorrhea for consecutive 2 months or more * being treated for hereditary diseases, mental disorder, hypertension, diabetes mellitus, or musculoskeletal impairments * taking any medication or supplements for weight control
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| body fat percent | Change from baseline body fat percent at 12 weeks | Changes in body fat percent during 12 weeks |
| acylated ghrelin | Change from concentrations of baseline acylated ghrelin at 12 weeks | Changes in concentrations of acylated ghrelin during 12 weeks |
| desacylated ghrelin | Change from concentrations of baseline desacylated ghrelin at 12 weeks | Changes in concentrations of desacylated ghrelin during 12 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ghrelin O acyl transferase | Change from baseline concentrations of ghrelin O acyl transferase at 12 weeks | Changes in concentrations of ghrelin O acyl transferase during 12 weeks |
Countries
South Korea
Outcome results
None listed