Mobility Limitation
Conditions
Keywords
Rehabilitation, Aging, Mobility Skills, Cognitive Training
Brief summary
The goal of this study is to evaluate the efficacy of multifaceted rehabilitation program in Veterans 65 years and older. This study will also examine the neuromuscular and cognitive attributes that contribute to clinically meaningful improvements in mobility; and determine whether a novel mode of cognitive training can enhance cognition among mobility limited primary care Veterans 65 years and older.
Detailed description
This study is a randomized control pilot study. All participants will receive rehabilitative exercise addressing mobility skills. In addition, one group will be will receive additional cognitive training. Randomization is stratified according to screening mobility and cognitive score.
Interventions
OTHERInVEST: Increased Velocity Exercise Specific to Task
Functional Power Training
OTHERTAPAT: Tonic and Phasic Alertness Training
Computerized cognitive training.
Sponsors
VA Boston Healthcare System
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Intervention model description
Randomized Pilot Study
Eligibility
Sex/Gender
ALL
Age
65 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 65-90 * History of fall in the past year OR difficulty or task modification with climbing one flight of stairs or walking ½ mile (6 blocks) * Community Dwelling * Ability to speak and understand English
Exclusion criteria
* Presence of a terminal disease (e.g. receiving hospice services, metastatic cancer * Major medical problem interfering with safe and successful testing (i.e. history of hip replacement with recurrent dislocation; uncontrolled hypertension, use of supplemental oxygen * Myocardial infarction or major surgery in previous 3 months * Planned major surgery (e.g. joint replacement) * Baseline Short Physical Performance Battery Score \<4 or \>10 * Modified Mini Mental Status Examination score of ≤77 out of 100 * Inability to safely complete the 400 meter walk test
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline Late-Life Function and Disability Instrument at 6 weeks | Baseline, 6 weeks | Function domain and the advanced and basic lower extremity function sub-domains of the Late-Life Function and Disability Instrument |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline Figure-of-8 Performance 6 weeks | Baseline, 6 weeks | — |
| Change from Baseline 400 Meter Walk Test at 6 weeks | Baseline, 6 weeks | — |
| Change from Baseline Short Physical Performance Battery (SPPB) at 6 weeks | Baseline, 6 weeks | Range: 0-12; higher score better physical performance |
| Change from Baseline Clock-in-the-Box Test at 6 weeks | Baseline, 6 weeks | — |
| Change from Baseline Trail Making Test at 6 weeks | Baseline, 6 weeks | — |
| Change from Baseline Letter Fluency Test at 6 weeks | Baseline, 6 weeks | — |
| Change from Baseline Hopkins Verbal Learning Test at 6 weeks | Baseline, 6 weeks | — |
| Change from Baseline Cognitive Performance at 6 weeks | Baseline, 6 weeks | — |
Countries
United States
Outcome results
None listed