Lateral Amyotrophic Sclerosis, Venous Thrombo-embolic Desease
Conditions
Keywords
lateral amyotrophic sclerosis, venous thrombo-embolic desase, pulmonary embolism, deep venous thrombosis
Brief summary
Venous thrombo-embolic (VTE) rates could be high in patients with amyotrophic lateral sclerosis (ALS). Indeed, the rate of VTE in this specific population could be 7-fold higher in this population. Predictiv factors of VTE in patients with ALS are mobility reduction and neurological paralysis. However, to our knowledge, medical littérature is poor concerning VTE and ALS association. Our first aim is to define annual rate of VTE in ALS population.Then we aim to identify predictiv factors of VTE in this specific population. The studied population is Brest universitary hospital cohort of ALS patient included between 2000 and 2019.
Interventions
None listed
Sponsors
University Hospital, Brest
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients with amyotrophic lateral sclerosis defined by revised El Escorial score criteria followed in competence centre of Brest Universitary Hospital during 2000 to 2019
Exclusion criteria
* no consent * other neuro-degenerativ diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of venous thrombo-embolic eventsrate per year in amyotrophic lateral sclerosis patients followed between 2000 and 2019 in Brest universitary hospital | 19 years | pulmonary embolism and deep venous thrombosis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of predictiv factors of venous thrombo-embolism events in amyotrophic lateral sclerosis population followed in Brest universitary hospital between 2000 and 2019 | 19 years | immobilization, impairment of respiratory function,, mecanical ventilation, denutrition, artificial nutrition |
Countries
France
Outcome results
None listed