Comparison of ONSD and rSO2 Measurements Between General and Spinal Anesthesia in C-Section

Comparison of Optic Nerve Sheath Diameter and Cerebral Regional Oxygen Saturation Measurements Between General and Spinal Anesthesia Applications in C-Section

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04446013

Enrollment

Registered

2020-06-24

Start date

2020-05-15

Completion date

2020-07-30

Last updated

2020-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intracranial Pressure Increase

Keywords

optic nerve sheath diameter, intracranial pressure, intraabdominal pressure, cerebral regional oxygen saturation, c-section

Brief summary

General anesthesia and regional anesthesia can be chosen in cesarean operations. Endotracheal intubation and mechanical ventilation are components of general anesthesia. Endotracheal intubation has been shown to cause increased intracranial pressure. There is not enough information about the effect of spinal anesthesia on intracranial pressure during cesarean operations. Increased intracranial pressure can cause neurological complications by disrupting brain perfusion. For this reason, the investigators think that the safe anesthesia method should be determined especially in pregnant patients who are at risk of increased intracranial pressure.

Interventions

OTHEROptic Nerve Sheath Diameter Measurement

The change in intracranial pressure via optic nerve sheath diameter measurement

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 49 Years

Healthy volunteers

Yes

Inclusion criteria

* Undergoing elective c-section operation * Age between 18-49 * ASA I-II * Gestational week ≥ 36

Exclusion criteria

* Ophthalmologic disease and optic nerve pathology * Increased intracranial pressure * History of cerebrovascular disease * Cases where spinal anesthesia is contraindicated * Emergency cesarean category level 1

Design outcomes

Primary

Measure	Time frame	Description
Change in Optic Nerve Sheath Diameter	Throughout the surgery	The change in intracranial pressure via optic nerve sheath diameter measurement during c-section among 5 time point.
Change in regional cerebral oxygen saturation	Throughout the surgery	The change in regional cerebral oxygen saturation during c-section among 5 time point.

Secondary

Measure	Time frame	Description
Perioperative Hemodynamic Parameters	Throughout the surgery	Mean arterial pressure in mmHg

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026