SARS-CoV-2
Conditions
Keywords
Hyposmia, Anosmia, Olfactory Dysfunction, COVID-19, SARS-CoV-2
Brief summary
We aim to understand the mechanism of olfactory dysfunction in COVID-19.
Detailed description
In December 2019, a new coronavirus causing severe acute respiratory syndrome was described in Wuhan, China. This virus, later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread worldwide and has been designated a pandemic by the World Health Organization. By the beginning of March 2020, several Ear, Nose, Throat societies raised awareness of a frequent association between coronavirus disease 2019 (COVID-19) and smell disorders. In the present study, the investigators wish to begin to understand the pathogenesis of olfactory dysfunction in COVID-19.
Interventions
OTHERSampling of tissue
In all groups of participants, tissue from the nasal cavity and olfactory system will be surgically removed
Sponsors
Max Planck Research Unit for Neurogenetics
AZ Sint-Lucas Brugge
Universitair Ziekenhuis Brussel
Hospital Clinic of Barcelona
Universitaire Ziekenhuizen KU Leuven
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
\- Deceased hospitalised patients, tested positive or negative for SARS-CoV-2 for patient or control group respectively
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of SARS-CoV-2 in the sampled tissue | Immediately after death | In the sampled tissues, the investigators will determine presence of SARS-CoV-2 by means of immunohistochemistry, RNA-scope and spatial transcriptomics |
Countries
Belgium
Contacts
Primary ContactLaura Van Gerven
Backup ContactMarnick Clijsters
Outcome results
None listed