Lumbar Spinal Stenosis (LSS)
Conditions
Keywords
paraspinal muscle atrophy (MA), sagittal pelvic alignment, degenerative spine diseases, stenosis grade (SG), degenerative LSS, Goutallier classification
Brief summary
This study is to evaluate the correlation between muscle atrophy (MA), sagittal alignment, and stenosis degree in patients with lumbar spinal Stenosis (LSS). From existing radiological images, specific radiographic parameters will be extracted. General Information (Age, sex, levels of stenosis, duration of symptoms) will be extracted from patient files.
Interventions
OTHERradiographic data collection
From existing radiological Images (upright standing X-ray and supine MRI of the lumbar spine), specific radiographic parameters will be extracted
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of degenerative lumbar spinal stenosis * Upright standing sagittal plane X-ray of lumbar spine with clear visibility of pelvis sacrum and femoral head * MRI of the lumbar region with clear visibility of different muscle atrophy grade * Consent that health related information can be used for research was signed
Exclusion criteria
* Other spinal disease such as severe scoliosis, fracture, spondylolisthesis and ankylosing spondylitis. * Neuromuscular diseases such as M.Parkinson or multiple sclerosis * Previous surgery of the spine * Infection and/or malignancy tumor with involvement of the bony or soft tissue structures of the spine * Presence of a documented consent dissent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Severity of muscle atrophy (MA) from supine Magnetic Resonance Imaging (MRI) of lumbar spine | single time-point at baseline | Muscle atrophy stage will be observed using Goutallier classification * Stage 0: No fatty infiltration * Stage 1: Few fatty streaks within the muscle * Stage 2: Less than 50% fat within the muscle * Stage 3: 50% of fat within the muscle * Stage 4: more than 50% fat with in the muscle. The MA stage will be observed in MRI of 5 lumbar disc levels (L1-S1). The MA stage of patients will be calculated as average stage of five lumbar segments. |
| Pelvic incidence (PI): Pelvic alignment from standard upright standing sagittal plane X-ray of lumbar spine with clear visibility of pelvis sacrum and femoral heads | single time-point at baseline | Pelvic incidence (PI): The angle between the line perpendicular to the sacral endplate at its midpoint and a line connecting this point to the axis of the femoral head. |
| Severity of stenosis from supine MRI of lumbar spine | single time-point at baseline | Stenosis grade will be observed using Schizas classification (Schizas et al., 2010) * Grade 1: Dural sac party occupied by the rootlets; Cerebrospinal fluid clearly visible; No stenosis * Grade 2: Rootlets occupy whole dural sac; Some cerebrospinal fluid visible; Moderate stenosis. * Grade 3: Rootlets not visible; No cerebrospinal fluid visible; Epidural fat posteriorly; Severe stenosis. * Grade 4: Rootlets not visible; No cerebrospinal fluid; No epidural fat; Extreme Stenosis. The most severe level will be regarded as the stenosis grade of the patients. |
| Pelvic tilt (PT): Pelvic alignment from standard upright standing sagittal plane X-ray of lumbar spine with clear visibility of pelvis sacrum and femoral heads | single time-point at baseline | Pelvic tilt (PT): The angle formed by a vertical line through the center of the femoral heads and the line from the center of the femoral axis and the midpoint of the sacral end plate. |
| Sacral slope (SS): Pelvic alignment from standard upright standing sagittal plane X-ray of lumbar spine with clear visibility of pelvis sacrum and femoral heads | single time-point at baseline | Sacral slope (SS): The angle formed between the horizontal and the sacral end plate. |
| Lumbar lordosis (LL): Pelvic alignment from standard upright standing sagittal plane X-ray of lumbar spine with clear visibility of pelvis sacrum and femoral heads | single time-point at baseline | Lumbar lordosis (LL): The sagittal angle formed between the superior end plate of L1 and the sacral end plate |
Countries
Switzerland
Outcome results
None listed