Osteoporosis, Sarcopenia
Conditions
Brief summary
Osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. Dynamic-resistance exercise (DRT) might be the most powerful agent to fight osteosarcopenia. Indeed, in the present FrOST study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (HIT)-DRT on bone mineral density (BMD), sarcopenia and other health related parameters in osteosarcopenic men. However, after a short training break, COVID-19 induced lock down prevented a re-start of the HIT resistance exercise training in the FrOST cohort. The aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.
Interventions
None listed
Sponsors
Friedrich-Alexander-Universität Erlangen-Nürnberg
University of Erlangen-Nürnberg Medical School
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
74 Years to 95 Years
Healthy volunteers
No
Inclusion criteria
* participants of the FrOST study (NCT03453463)
Exclusion criteria
* medication and diseases with potential impact on study outcomes during the last 26 weeks.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SMI | Change from Baseline to 26 weeks | Skeletal muscle mass index (appendicular skeletal muscle mass / body height; kg/m2) as determined by Dual Energy x-Ray Absorptiometry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| BMD-hip | Change from Baseline to 26 weeks | Bone Mineral Density at the total hip as determined by Dual Energy x-Ray Absorptiometry |
| Sarcopenia-Z-Score | Change from Baseline to 26 weeks | Z-Score of parameters constituting the metabolic syndrome (i.e. SMI, hand-grip strength, gait velocity) |
| Fat infiltration thigh muscles | Change from Baseline to 26 weeks | Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging |
| BMD-LS | Change from Baseline to 26 weeks | Bone Mineral Density at the Lumbar Spine as determined by Dual Energy x-Ray Absorptiometry |
| Maximum hip-/leg extensor strength | Change from Baseline to 26 weeks | Maximum hip-/leg extensor strength as determined by an isokinetic leg press |
| Metabolic Syndrome Z-Score | Change from Baseline to 26 weeks | Metabolic Syndrome Z-Score based on the definition of the International Diabetes Federation including waist circumference, resting glucose, HDL-cholesterol, triglyzerides, mean arterial blood pressure) |
| Self rated physical performance | Change from Baseline to 26 weeks | Late-Life Function and Disability Index of McAuley et al. |
| Fat infiltration para-vertebral muscles | Change from Baseline to 26 weeks | Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging |
Countries
Germany
Outcome results
None listed