Healthy Athletes
Conditions
Brief summary
It has recently been suggested that cocoa may improve exercise performance and recovery. This study aim to evaluate the plasma and fecal metabolome after 10 weeks of cocoa supplementation during the training period in recreational athletes to detect possible metabolites involved in the observed benefits of cocoa in athletes
Interventions
DIETARY_SUPPLEMENTcocoa
Sachets of 5 grams of cocoa daily supplementation
DIETARY_SUPPLEMENTPlacebo
Sachets of 5 grams of maltodextrin daily supplementation
Sponsors
Universidad Europea de Madrid
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-45 years of age * high physical condition (VO2 ≥ 55 ml/kg/min) * BMI 18-25 kg/m2
Exclusion criteria
* antibiotics intake during 3 months prior to the study, * smoking * nutritional complements * ergogenic complements * prebiotics * probiotics * vegetarian or vegan diet * chronic medication * gastrointestinal surgery * Any diagnosed disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fecal microbiota | Changes from baseline to 10 weeks of intervention | Abundance of bacterial taxa determined by 16SRNAr gene sequencing |
| Fecal metabolome profile | Changes from baseline to 10 weeks of intervention | Abundance of fecal metabolites, metabolic networks, and metabolic pathways determined by High Pressure Liquid Chromatography-Mass Spectrometry |
| Plasma metabolome profile | Changes from baseline to 10 weeks of intervention | Abundance of blood metabolites, metabolic networks, and metabolic pathways activity determined by High Pressure Liquid Chromatography-Mass Spectrometry |
Countries
Spain
Outcome results
None listed