Pancreatic Diseases, Pancreatitis, Pancreatitis, Acute Necrotizing
Conditions
Brief summary
The LPN procedure is performed under general anesthesia. The transperitoneal access to peripancreatic space is via the gastro-colic ligament and greater omentum, effusion and pus is removed by laparoscopic forceps and suction. Laparoscopic cholecystectomy (LC) is performed during the LPN procedure on patients with indication. The NPN procedure is followed by the standard retroperitoneal approach. After the catheter is exchanged over a guide wire and serially dilated up from 6F to 24F followed by Seldinger technique, the access track to the necrotic cavity is established. A nephroscope is inserted into the cavity through the track for debridement. Using forceps and suction, the peripancreatic solid necrotic tissue and pus is grasped and removed. A large-bore irrigating drain is left in the cavity, with continuous irrigation by warm normal saline solution at a rate of 100-125 ml/h after surgery.
Interventions
PROCEDUREDual-scopic pancreatic necrosectomy（DPN）
Treatment of Acute Severe Pancreatitis with DPN
Sponsors
First People's Hospital of Hangzhou
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients ages 18 or above admitted to UPMC with a diagnosis of AP based on at least 2 of the following criteria:(i) abdominal pain characteristic of AP (ii) serum amylase and/or lipase ≥ 3 times the upper limit of normal (iii) characteristic findings of AP on abdominal CT scan will be screened for study enrollment.
Exclusion criteria
* Less than 18 years of age * Pregnant women * Presence of renal dysfunction (Cr\>1.5mg/dL) * Pre existing heart dysfunction or NYHA classification score above III * Coagulation disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Complication Rate | through study completion, an average of 24 weeks | Proportion of patients with perioperative complications |
| Mortality | through study completion, an average of 24 weeks | Proportion of patients dying in the perioperative period |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospital stay | through study completion, an average of 24 weeks | Length of hospital stay |
Countries
China
Contacts
Primary ContactYang Cai
Outcome results
None listed