Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04443400

Enrollment

100

Registered

2020-06-23

Start date

2020-01-01

Completion date

2021-12-31

Last updated

2020-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Radiation Therapy

Brief summary

The purpose of this study is to detecte and predict early subclinical cardiac damage induced by thoracic radiation therapy based on two-dimensional speckle tracking echocardiography combined with multiple circulating biomarkers.

Detailed description

This is a monocentric prospective cohort study in which 100 patients treated for malignant tumors and with cardiac radiation exposure will be included.All patient will be followed for 12 months after radiotherapy. Echocardiography, 2D STE parameters and circulating biomarkers will be collected.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* with malignant tumors * will receive radiotherapy * with cardiac exposure during the radiotherapy process * could receive regular follow-up for 12 months * written informed consent

Exclusion criteria

* satisfactory echocardiographic images could not be obtained * moderate or severe valvular disease * cardiomyopathy * congenital heart disease * refractory hypertension * coronary artery disease\* * heart failure * arrhythmia requiring intervention * pericarditis * acute myocarditis * participating in other clinical studies of drug intervention * severe liver and kidney dysfunction * autoimmune disease * pulmonary hypertension coronary artery disease: at least 50% stenosis besed on previous coronary angiography or CTA, or with a history of percutaneous coronary stent implantation. \*: with LVEF\<50%, unstable angina，or acute myocardial infarction within 3 months.

Design outcomes

Primary

Measure	Time frame	Description
Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy	2020-2021	To detecte early subclinical cardiac damage induced by thoracic radiation therapy, based on two-dimensional speckle tracking echocardiography combined with multiple circulating biomarkers

Countries

China

Contacts

Primary ContactDan Zhu, M.D.

andrea_zhu@163.com+8613810103532

Backup ContactTingcui Li

tingcui2019@163.com+8618801236290

Outcome results