Adolescent, Adult, Female, Follow-up Studies, Human, Lens Implantation, Intraocular, Male, Myopia, Phakic Intraocular Lenses, Postoperative Period, Preoperative Period, Prospective Studies, Retinal Vessels, Tomography, Optical Coherence
Conditions
Brief summary
To observe the retinal microvascular alteration during 3 months follow-up after Implantable Collamer Lens (ICL) operation in moderate and high myopia patients using quantitative optical coherence tomography angiography (OCTA) analysis.
Detailed description
The study object is moderate and high myopia patients, underwent ICL implantation. OCTA was used to image the superficial and deep retinal vascular plexuses before ICL implantation surgery and at 3 months follow-up. OCTA images were corrected for magnification, skeletonized, separated the large vessels and partitioned. Retinal microvascular density was measured by using fractal dimension analysis. The aim of this study was to uncover potential retinal vascular network alterations induced by ICL implantation surgery.
Interventions
DEVICEOptical Coherence Tomography Angiography
AngioVue (Optovue, Fremont, CA, USA) was used to capture the OCTA images before ICL surgery and at 3 months follow-up.
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 to 45 years old; * Binocular myopia, with a refraction of greater than -3 diopters (D); * anterior chamber depth (ACD, measured from the endothelium to the crystalline lens) \> 2.8 mm; * corneal endothelial cell count (cECC) ≥ 2000 cells/mm2; * stable refraction at least 1 year before surgery; * unsatisfactory vision with contact lenses or spectacles.
Exclusion criteria
* history of intraocular surgery * other ocular pathology (uveitis, glaucoma, cataract, keratoconus, severe dry eye, etc.) * other serious systemic disease (diabetes, uncontrolled hypertension, severe hyperthyroidism, etc.).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Retinal microvessels density | 3 months postoperatively | Retinal microvessels density was measured with fractal dimension analysis by using Matalb (The Mathworks, Inc., Natick, MA, USA) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Best corrected visual acuity | 3 months postoperatively | BCVA was evaluated by decimal Snellen and converted to the logarithm of the minimum angle of resolution (logMAR) for statistical analysis. |
| Mean refractive spherical equivalent | 3 months postoperatively | MRSE = Spherical power + 0.5 \* Cylindrical power |
| Intraocular pressure | 3 months postoperatively | The IOP was measured using a non-contact tonometer (CT-80; Topcon, Tokyo, Japan). |
| Vault | 3 months postoperatively | The central vault of the ICL (distance from posterior surface of ICL to the crystalline lens) was measured using Optical Coherence Tomography (Visante; Carl Zeiss Meditec, Jena, Germany) |
Countries
China
Outcome results
None listed