Analgesia
Conditions
Keywords
dexmedetomidine, fentanyl, bupivacaine, knee arthroscopy, postoperative analgesia
Brief summary
The aim of this study is to evaluate analgesic effects Bupivacaine, Bupivacaine plus Dexmedetomidine and Bupivacaine plus Fentanyl in relieving pain after knee arthroscopic surgery.
Detailed description
Forty-five patients ASA I - II aged 21-45 years for elective knee arthroscopy were divided into 3 groups: Group B, BD and BF. Group B received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml saline. Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug). Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug). The time of first request of analgesia and analgesic effect by VAS during the first 24 hr. postoperatively are recorded.
Interventions
DRUGDexmedetomidine
Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug).
DRUGFentanyl
Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug)
DRUGBupivacain
Group B received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml saline.
Sponsors
Zagazig University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
anesthetist not sharing in the study will assess patient
Intervention model description
analgesia for postoperative pain after knee arthroscopy: dexmedetomidine+bupivacaine, fentanyl+bupivacaine , bupivacaine
Eligibility
Sex/Gender
ALL
Age
21 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Either sex, * Age 21-45 years, * American Society of Anesthesia (ASA) I - II for elective knee arthroscopy.
Exclusion criteria
* The patients with history of hepatic and renal diseases, psychiatric disorders, * Prolonged intake of (NSAIDS, opioids and tricyclic antidepressant), * Allergy to study drugs and patient who received analgesics up to 24 hr. before surgery were excluded from this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of postoperative analgesia | For 24 hours postoperative | start from intra-articular injection of the drug to the time of first request of analgesia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pain intensity on mobilization of operated knee (dynamic) | measured immediately preoperative 0 minute ( admission receiving area) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) |
| total dose of rescue analgesia ( pethidine) | within 24 hours postoperative | total consumption of rescue analgesia (pethidine) postoperative |
| The number of participants with bradycardia, itching and hypotension | Within 24 hours postoperative | The number of participants with bradycardia less than 50 beat per minute, itching and hypotension if mean arterial blood pressure less than 20% of basal ) |
| patient satisfaction | within 24 hours postoperative | Patient satisfaction by five point Likert-Like verbal rating scale by asking the patient how they evaluate the experience with the analgesic management after the the surgery? (5-very satisfied, 4-satisfied, 3-neutral, 2-dissatisfied, 1-very dissatisfied) |
| pain intensity at rest (static) | measured immediately preoperative 0 minute ( admission receiving area) | measured by VAS on 0-10 cm scale (0- no pain and 10-the worst pain) |
Countries
Egypt
Outcome results
None listed