Penicillin Allergy
Conditions
Brief summary
Children are often reported to have antibiotics allergies, with approximately 10% of the US population labeled as allergic to an antibiotic. Recent studies have demonstrated that a large majority of children with a penicillin allergy label do not have a true IgE-mediated allergy. Appropriately delabeling antibiotic allergies has been shown to improve patient care outcomes and lower health care costs. However, efforts to implement these assessments in practice are lacking, particularly in the hospital setting. Therefore, there is a need for hospital-based risk assessment and delabeling strategies for hospitalized children. The investigator's objective is to determine the feasibility of implementing a hospital-based approach to penicillin allergy risk stratification and evaluation of patients at low-risk for true allergy.
Interventions
OTHERPenicillin Allergy Risk Stratification and Evaluation
This standard of care intervention will provide an antibiotic allergy risk stratification assessment and subsequent amoxicillin oral challenge in patients who stratify as low risk for true allergy
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
Vanderbilt University Medical Center
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients admitted to Vanderbilt children's hospital admitted to a Pediatric Hospital Medicine service with a penicillin allergy reported in their chart who are medically stable
Exclusion criteria
* Known pregnancy * Patients without a primary care provider
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of Intervention Measure | Within 2 weeks of hospital discharge | Qualitative survey to assess feasibility of intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Acceptability of Intervention Measure | Within 2 weeks of hospital discharge | Qualitative survey to assess acceptability of intervention |
| Intervention Appropriateness Measure | Within 2 weeks of hospital discharge | Qualitative survey to assess appropriateness of intervention |
Countries
United States
Outcome results
None listed