Endometriosis, Endometriosis-related Pain, Endoplasmic Reticulum Stress
Conditions
Brief summary
The correlation between painful symptoms (dysmenorrhea, dysparonia, dysuria, chronic pelvic pain) symptoms and endoplasmic reticulum stress was investigated in 86 patients diagnosed with endometriosis. For this, xbp-1 (x box binding protein-1) level was measured in patients. XBP-1 is an endoplasmic reticulum stress indicator and is known to be involved in pain pathogenesis.
Detailed description
Women between the ages of 18-50 who were diagnosed with endometriosis by surgery and ultrasound, without known rheumatological or metabolic diseases were included in the study. Most of the patients are composed of newly diagnosed patients.
Interventions
OTHERxbp-1 - endometriosis patients group
Patients diagnosed with endometriosis by surgery and ultrasound and whose xbp-1 level was examined
Sponsors
Kanuni Sultan Suleyman Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* diagnosed endometriosis with ultrasound or surgery * no metabolic diseases * no rheumatological diseases
Exclusion criteria
* Immune modulator, hormonal, anti-inflammatory use history in the last 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of the correlations between the results of XBP-1 levels and the stages and pain symptoms of endometriosis. | 5 months |
Secondary
| Measure | Time frame |
|---|---|
| serum XBP-1levels in patients wit endometriosis | 5 months |
Countries
Turkey (Türkiye)
Outcome results
None listed