Influence of Positive Margins on Tumour Recurrence and Overall Survival After Gastrectomy for Gastric Cancer

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04439812

Enrollment

267

Registered

2020-06-19

Start date

2010-01-01

Completion date

2018-12-31

Last updated

2020-06-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stomach Neoplasms

Keywords

Gastric cancer, gastrectomy, R1, positive margins, recurrence, overall survival, prognosis

Brief summary

Incidence of positive surgical margins after curative gastrectomy ranges from 1% to 20%. It has been suggested that positive surgical margins is an adverse prognosis factor, with a higher local recurrence and worse overall survival (OS). However, the management of these patients remains unclear.

Interventions

OTHERObservation

The primary aim of this study was to evaluate the influence of positive margins on the tumour's recurrence and OS after gastrectomy for GC. The secondary outcome was to analyse the possible confounding factors that could affect the recurrence and OS after gastrectomy.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* all consecutive patients who underwent an oncological gastrectomy due to gastric cancer, between January 2010 and December 2018 at Ramon y Cajal University Hospital.

Exclusion criteria

* distant disease (including patients with positive cytology), early postoperative mortality (within 30 days after surgery) and follow-up data not available. Resections in patients with palliative intent were also excluded.

Design outcomes

Primary

Measure	Time frame
evaluate the influence of positive margins on the tumour's recurrence and OS after gastrectomy for GC	8 years

Secondary

Measure	Time frame
The secondary outcome was to analyse the possible confounding factors that could affect the recurrence and OS after gastrectomy.	8 years

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026