Rheumatoid Arthritis
Conditions
Keywords
Rheumatoid Arthritis, Biochemical Parameters, exercise
Brief summary
Background: RA may progress with articular and non-articular involvement.Depression prevelance is found to increase for RA patients according to healthy population and to be correlated with pain, decreased quality of life, fatigue and physical disability.BDNF level was found significantly lower in RA patients with depression. Aim of this study is to investigate the variation of BDNF, VEGF, TNF- α, IL-6, IL-1β, irisin and α- Klotho levels following acute exercise. Methods: This study included 45 RA patients and 45 age and sex matched healthy controls. Blood samples from all subjects were taken and centrifuged before and immediately after the exercise intervention.
Interventions
OTHERAerobic exercise
Aerobic exercise will be performed to all participants for a single session. Maximum heart rate was calculated for each subject (220 - age) and a heart rate monitor (Polar FT 100, China) will be used to follow subjects' heart rate during aerobic exercise.
Sponsors
Gazi University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients who were aged between 18-65 years, * Patients who got diagnosed according to American College of Rheumatology criteria * Patients who were being followed at Firat University Department of Rheumatology
Exclusion criteria
* Patients who had regular exercise habits, malignancy, pregnancy, incorporation, * Patients who took anti-TNF treatment * Patients who had changes of medical treatment in last 3 months * Patients who diagnosed with Fibromyalgia Syndrome and Osteoarthritis for lower extremity * Patients who had cardiac symptoms according to New York Heart Association * Patients who had dysfunction that can prevent physical activity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Irisin | 1 minute | Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention. Obtained serums will be stored at the laboratories of Firat University. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| BDNF, VEGF, TNF- α, IL-6, IL-1β and α- Klotho | 1 minute | Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention. Obtained serums will be stored at the laboratories of Firat University. |
Countries
Turkey (Türkiye)
Contacts
Primary ContactSongul B Yentur
Backup ContactSüleyman S Koca, Prof. Dr.
Outcome results
None listed