Effects of Nopal Fractions on Postprandial Glucose Regulation and Appetite Variables in Healthy Humans

Evaluation of Potentially Bioactive Foods With Regard to Their Effects on Cardiometabolic Test Markers and Cognitive Variables

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04439630

Enrollment

Registered

2020-06-19

Start date

2020-07-01

Completion date

2020-08-01

Last updated

2020-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appetite Sensations, Glucose Tolerance

Keywords

healthy subjects, diabetes prevention, obesity prevention

Brief summary

Postprandial effects of Nopal fractions on glucose and appetite regulation will be investigated in healthy humans, in a randomised controlled crossover trial

Interventions

DIETARY_SUPPLEMENTNopal fractions

Nopal flour were divided in two fractions and mixed in two different test breads

DIETARY_SUPPLEMENTTest product without the active components

Test product without the active components

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Masking description

Participants knew which test products that were included in the study, but not the consumption order

Intervention model description

randomised crossover study in healthy young adults with normal BMI

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy * non-smokers * diet accordance with the Nordic Nutrition Recommendations * BMI: 18.5-25 kg/m2

Exclusion criteria

* metabolic disorders * food allergies * no probiotics or other food /supplement which may interfere with the study

Design outcomes

Primary

Measure	Time frame	Description
postprandial glucose tolerance	0-180 min after start of the meal	effects on postprandial glucose tolerance after intake of test products at breakfast. Measurements were performed at fasting (time = 0 min) and at 15, 30, 45, 60, 90, 120, 150 and 180 min.
postprandial insulin concentrations	0-180 min	effects on serum insulin concentrations after intake of test products at breakfast. Measurements were performed at fasting (time = 0 min) and at 15, 30, 45, 60, 90, 120, 150 and 180 min.

Secondary

Measure	Time frame	Description
subjective appetite variables	0-180 min	Subjective appetite variables (hunger, satiety, desire to eat) after intake of test products at breakfast, using a 100 mm Visual Analogue Scale (VAS) on a white paper. Except from a center mark in the center of the scale there was no other visible marks. Measurements were performed at fasting (time = 0 min) and at 15, 30, 45, 60, 90, 120, 150 and 180 min.

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026