Aortic Dissection, Aortic Dissection, Familial, With or Without Aortic Aneurysm, Family Research
Conditions
Keywords
aortic dissection, pathogenesis, familial inheritance, susceptibility gene
Brief summary
Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.
Interventions
GENETICmovement
aortic dissection or aneurysm patients this is an observation cohort study about a Non-syndromic Familial Aortic Dissection without intervention.
Sponsors
Chinese Medical Association
Study design
Observational model
FAMILY_BASED
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Family inclusion criteria: 1 at least one person in each generation of a family has aortic dissection, and at least two generations of members can be included;
Exclusion criteria
* Pedigree
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| gege | 2023 | Discovery of known or unknown genes |
Countries
China
Contacts
Primary ContactJing Zaiping, professor
Outcome results
None listed