Hypoxic Brain Injury, Maternal Death
Conditions
Brief summary
Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) using high flow oxygen therapy for preoxygenation and oxygen supplementation during apnoea has shown promising results
Detailed description
Eeffective preoxygenation followed by apnoeic oxygenation enables anaesthesiologists to safely prolong the apnoea time which is the time (seconds) of apnea following preoxygenation and muscle relaxation before to peripheral oxygen saturations (SpO2) decreases by 2%.
Interventions
OTHERF Group
In Group F, pregnant females will be preoxygenated with 100% oxygen using a tight-fitting face mask at a rate of 6 L/min for 3 min with end-tidal gas monitoring.
OTHERH Group
In Group H, high-flow humidified oxygen warmed to 37°C will be delivered through nasal cannula at the rate of 30 L/ min for 30 seconds then 50 liters per minute for a further 150 seconds.
Sponsors
Alexandria University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* pregnant females * Of American Society of Anesthesiologists (ASA) physical Status I and II * For elective cesarean section under general anesthesia
Exclusion criteria
* with room air saturation of \<98% * anticipated difficult airway * anticipated obstetric risk factor or precious baby * chronic obstructive pulmonary disease * thyrotoxicosis * pheochromocytoma * hyperkalaemia * significant cardiac illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| measure the time of safe apnea | 10 minutes after induction | The apnea time will start from the onset of cessation of breathing as evidenced by a flat line in the capnogram with the absence of chest movements |
Countries
Egypt
Contacts
Primary ContactRehab A. Abd Elaziz, Ass. Prof.
Outcome results
None listed