The Reproducibility and Clinical Utility of an Abbreviated Fat Tolerance Test

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04437459

Enrollment

Registered

2020-06-18

Start date

2018-10-08

Completion date

2019-07-31

Last updated

2020-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyslipidemias, Metabolic Syndrome

Brief summary

This study aims to evaluate the reliability of a shortened fat tolerance test (abbreviated fat tolerance test, or AFTT) for measuring post-meal lipids in human blood. The reliability of the triglyceride results in this test are compared to the reliability of the glucose results from an oral glucose tolerance test (OGTT), a widely-used and clinically accepted metabolic test.

Interventions

OTHERHigh-fat shake

Participant consumes a high-fat test shake. Blood is drawn before and 4 hours after this shake to measure triglycerides.

OTHERPure glucose solution

Participant consumes 75 grams of pure glucose. Blood is drawn before and 2 hours after this drink to measure glucose.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Free of chronic disease * Normal (healthy) fasting glucose and triglycerides

Exclusion criteria

* Presence of pace-maker * Pregnant * Using tobacco products * Using medications or dietary supplements that could modify primary outcomes

Design outcomes

Primary

Measure	Time frame	Description
Reliability of the Change in Triglycerides after a High-Fat Meal	The two fat tolerance tests are separated by 1 week.	Participants complete two fat tolerance tests. In each test, triglycerides are measured in blood immediately before and 4 hours after consumption of a high-fat meal. The reliability/agreement in measuring the triglyceride change between the 2 tests is being determined.
Reliability of the Change in Glucose after Ingestion of a Glucose Solution	The two glucose tolerance tests are separated by 1 week.	Participants complete two glucose tolerance tests. In each test, glucose is measured in blood immediately before and 2 hours after consumption of a pure glucose solution. The reliability/agreement in measuring the glucose change between the 2 tests is being determined.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026