Hydromorphone, Analgesia, ICU
Conditions
Brief summary
Hydromorphone has a clear analgesic effect, and has few advantages in respiratory depression and gastrointestinal motility. The study will further explore the continuous pumping-dose of hydromorphone for ICU non-mechanical ventilation patients and monitor its effective plasma concentration as well as evaluates the safety and effectiveness of hydromorphone for ICU non-mechanical ventilation patients.
Interventions
DRUGHydromorphone
Intravenous analgesia using hydromorphone in ICU patients with non-mechanical ventilation(NS 40ML+ hydromorphone 10mg ，IV-Pump)
DRUGFentanyl
Intravenous analgesia using fentanyl in ICU patients with non-mechanical ventilation(NS 40ML+ fentanyl 0.5mg, IV-Pump)
DRUGButorphanol
Intravenous analgesia using butorphanol in ICU patients with non-mechanical ventilation(NS 40ML+ butorphanol 10mg，IV-Pump)
Sponsors
Nanfang Hospital, Southern Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years old; * Non-mechanical ventilation patients with expected ICU stay time \>24h * People with moderate to severe pain who need immediate analgesic treatment (NRS ≥ 4 or BPS ≥ 5 points, CPOT ≥ 3);
Exclusion criteria
* pregnancy； * can not get pain score from patients * allergy to drugs * ....
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| successful analgesic proportion | From date of using the intervention drugs until the date of leaving from icu, up to 28 days | Proportion of patients in each group who reached the target analgesia score range |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Score | From date of using the intervention drugs until the date of stopping using intervention drugs, up to 28 days | analgesia score, such as CPOT or NRS |
| dose of analgesics | From date of using the intervention drugs until the date of stopping using intervention drugs, up to 28 days | total dose of analgesics during the study |
| Adverse event | From date of using the intervention drugs until the date of discharge or death from any cause, up to 60 days | Adverse event during the study, including hypotension.et |
| ICU stay | from the date of entering icu until the date of leaving icu or death from any cause, up to 28 days. | duration of stay in ICU |
Countries
China
Contacts
Primary ContactHongbin Hu, doctor
Outcome results
None listed