Ankylosing Spondylitis
Conditions
Keywords
Muscle Powers, Functionality, Disease Activity
Brief summary
This study evaluates how the trunk and proximal girdle muscles are affected in male patients with ankylosing spondylitis, compared to healthy controls.
Detailed description
Ankylosing spondylitis is a chronic, inflammatory rheumatic disease with an unclear etiology which causes back pain and affects the functionality of axial skeleton. Besides the effect upon axial skeleton, the disease also affects the peripheral joints. In most patients, tenuous affection of peripheral joints occurs however, in some others the disease causes impaired spinal mobility and articular instability. This causes proximal girdle muscles and trunk muscles of the patients to be exposed to excessively stress and in conclusion deformities develop. Maximum force generated by a muscle or muscle group directly effects the physical ability of an individual, and manual muscle dynamometers are used to directly evaluate the muscle strength. In this manner the investigators aim to evaluate trunk and proximal girdle muscles' powers in male patients with ankylosing spondylitis and analyze the correlation between muscle powers, and functionality and disease activity.
Interventions
OTHERTruncal flexion-extension muscle power
Patient performs a maximum truncal flexion laying supine on the bed with cap of muscle tester placed on sternum,
OTHERTruncal extension muscle power
Patient performs a maximum truncal extension laying prone on the bed while the cap of manual muscle tester placed on vertebrae at the level of midline between superior angles of scapulae.
OTHERCervical flexion muscle power
Patient performs a maximum cervical flexion sitting while the cap of manual muscle tester placed on the middle of the forehead.
OTHERCervical extension muscle power
Patient performs a maximum cervical extension sitting while the cap of manual muscle tester placed on protuberantia occipitalis.
OTHERCervical lateral flexion muscle powers
Patient performs a maximum cervical lateral flexions on right and left sitting while the cap of manual muscle tester placed on relevant pterion.
OTHERShoulder flexion muscle power
Patient performs a maximum shoulder flexion of the dominant side on upright while the cap of manual muscle tester placed on midpoint of the line between anterior aspect of acromion and anterior elbow.
OTHERShoulder extension muscle power
Patient performs a maximum shoulder flexion of the dominant side on upright while the cap of manual muscle tester placed on midpoint of the line between posterior aspect of acromion and posterior elbow.
OTHERShoulder internal rotation muscle power
Patient performs a maximum shoulder internal rotation of the dominant side on upright while the cap of manual muscle tester placed on midpoint of the line between anterior elbow and wrist.
OTHERShoulder external rotation muscle power
Patient performs a maximum shoulder external rotation of the dominant side on upright while the cap of manual muscle tester placed on midpoint of the line between posterior elbow and wrist.
OTHERShoulder abduction muscle power
Patient performs a maximum shoulder abduction of the dominant side on upright while the cap of manual muscle tester placed on midpoint of the line lateral aspect of acromion and lateral epicondyle.
OTHERHip flexion muscle power
Patient performs a maximum hip flexion laying supine on the bed while the cap of manual muscle tester placed on middle of the anterior thigh.
OTHERHip extension muscle power
Patient performs a maximum hip extension laying prone on the bed while the cap of manual muscle tester placed on middle of the posterior thigh.
OTHERHip abduction muscle power
Patient performs a maximum hip abduction laying supine on the bed while the cap of manual muscle tester placed on middle of the lateral thigh.
OTHERHip internal rotation muscle power
Patient performs a maximum hip internal rotation laying supine on the bed while the cap of manual muscle tester placed on the midline between lateral condyle of femur and lateral malleolus.
OTHERHip external rotation muscle power
Patient performs a maximum hip external rotation laying supine on the bed while the cap of manual muscle tester placed on the midline between medial condyle of femur and medial malleolus.
This questionnaire evaluates the functionality in patients with AS. The ten questions that comprise the BASFI were chosen with input from patients with AS. The first 8 questions evaluate activities related to functional anatomical limitations due to the course of this inflammatory disease. The final 2 questions evaluate the patients' ability to cope with everyday life. A visual analogue scale (with 0 being easy and 10 impossible) is used to answer the questions on the test. The final score varies between 0 and 10.
This questionnaire evaluates the disease activity level in patients with AS. The BASDAI consists of a 0 - 10 scale measuring discomfort, pain, and fatigue (0 being no problem and 10 being the worst problem) in response to six questions asked of the patient pertaining to the five major symptoms of AS. The final score varies between 0 and 10.
OTHERThe Health assessment questionnaire (HAQ)
The Health assessment questionnaire (HAQ) is a questionnaire for the assessment of disability in an individual. The patients report the amount of difficulty they have in performing eight daily living activities. Each question asks on a scale ranging from 0 to 3 if the categories can be performed without any difficulty (scale 0) up to cannot be done at all (scale 3). The final score varies between 0 and 3.
Bath Ankylosing Spondylitis Metrology Index, a combined index to assess the spinal mobility. It evaluates the patients regarding cervical rotation, tragus-to-wall distance, lumbar flexion, lumbar lateral flexion and intermalleolar distance. The total score varies between 5 to 15 in patients with ankylosing spondylitis
Sponsors
Bezmialem Vakif University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Having a diagnosis of ankylosing spondylitis according to Modified NewYork criteria 2. Being male 3. Aged ≥18
Exclusion criteria
1. Severe cardiac or pulmonary or renal disease 2. Accompanying fibromyalgia 3. Severe psychiatric disorder 4. Other disease limiting spinal, shoulder or hip range of motion 5. Myopathy, neuropathy or radiculopathy that may cause muscle weakness 6. Using high dose steroids 7. Endocrinological disorders 8. Malignancy 9. Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cervical muscle powers | 1 day | Cervical flexion, extension, and lateral flexion muscle powers in kilograms as assessed with handheld dynamometer. |
| Truncal muscle powers | 1 day | Truncal flexion and extension muscle powers in kilograms as assessed with handheld dynamometer. |
| Shoulder girdle muscle powers | 1 day | Shoulder flexion, extension, abduction, internal rotation, and external rotation muscle powers in kilograms as assessed with handheld dynamometer. |
| Hip girdle muscle powers | 1 day | Hip flexion, extension, abduction, internal rotation, and external rotation muscle powers in kilograms as assessed with handheld dynamometer. |
Countries
Turkey (Türkiye)
Outcome results
None listed