COVID-19 Severe Pneumonia, Severe Pneumonia Due to Other Pathogene
Conditions
Brief summary
SARS-COV 2 infection might be responsible for sever pneumonia. Obesity seems to be a risk factor for severe SARS-COV 2 pneumonia. Lipid metabolism alteration are described with both obesity and sepsis. The aim of the present study was to describe association between lipid metabolism, obesity, sepsis inflammation and clinical outcome in COVID-19 patient with severe pneumonia compared with severe pneumonia caused by other pathogenes.
Interventions
BIOLOGICALbiological assays in particular on the lipid metabolism
bioassays carried out on samples already collected and conserved
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 2 of the following criteria: Cough/ Dyspnea/ Spitting/ Thoracic pain/ Hyperthermia (\>=38 °C) Hypothermia (\< 35°C) AND new radiologic pulmonary infiltrate * At admission or within 48 hours following hospital admission * With 2 qSOFA criteria: MAP =\< 100 mmHg, Respiratory Rate \>= 22, Glasgow score \< 15 OR on mechanical ventilation OR under vasopressor * Age \> 18 * affiliated to social security
Exclusion criteria
* Pregnancy * immunodepression * Pathology known to cause severe lymphopenia * hospitalisation within 3 month before inclusion AND sepsis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cholesterol concentration | Within 48 hours following hospital admission |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| LDL cholesterol / HDL cholesterol/ Lipoprotein size and composition/ Non esterified Fatty acid/ Triglyceridemia/ CETP and PLTP activity/ apolipoprotein canceration/ lipid peroxidation/ Pro and anti inflammatory profile. | Within 48 hours following hospital admission | Ventilator free days (28 days) |
Countries
France
Outcome results
None listed