Alveolar Bone Resorption
Conditions
Brief summary
the aim of this study is clinically and radiographically evaluate the use of advance platelet rich fibrin (A-PRF) versus platelet rich fibrin (PRF) in preservation of alveolar ridge following tooth extraction
Detailed description
systemically healthy patients who have at least one non-restorable tooth in the upper inter-bicuspid region and are not seeking immediate or early implant treatment will be allocated in this study after performing nonsurgical periodontal therapy and preoperative periapical therapy to evaluate and improve the condition of the periodontal tissues. Anesthesia will be given then flapless atraumatic extraction using periotomes followed by forceps after luxation. For all groups, the socket will be debrided using curette then * group A, the socket will be filled with A.PRF * group B the socket will be filled with PRF. * group C no bio-additive will be added. * Criss cross horizontal mattress suture will be applied to close the extraction wound. PRF and A-PRF preparation : 10 ml of blood will be drawn from each patient by vein puncture of the antecubital vein. * Plateletr ich fibrin (PRF) is 3000 rpm and 10 minutes without addition of anticoagulant * Advanced platelet rich fibrin (A-PRF) is 1300 rpm and 8 minutes.
Interventions
PROCEDUREPlatelet rich fibrin (PRF)
following atraumatic extraction of the tooth using periotomes , 10 ml of patient's blood will be drawn by vein puncture of the antecubital vein and prepared in a centrifuge at 3000 rpm for 10 minutes then criss horizontal mattress suture will be applied to close the extraction wound
following atraumatic extraction of the tooth using periotomes , 10 ml of patient's blood will be drawn by vein puncture of the antecubital vein and prepared in a centrifuge at 1300 rpm for 8 minutes then criss horizontal mattress suture will be applied to close the extraction wound
PROCEDUREblood clot
following atraumatic extraction of the tooth using periotomes, no bio-addative will be added and criss horizontal mattress suture will be applied to close the extraction wound
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with at least one non restorable tooth in upper inter-bicuspid region. * Stable periodontal condition with no acute periapical infection. * Systematically healthy conditions. * Cooperative patients. * Intact buccal plate of bone.
Exclusion criteria
* Smokers. * Patients seeking immediate or early implants. * Pregnant females. * Bone diseases. * Drugs and diseases that may affect platelet count or function.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in bucco-lingual dimensions | 6 months | clinical measurement using bone caliper in mm numerical |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in alveolar bone height | 6 months | radiographic measurement using CBCT in mm numerical |
| bone dentistry | 6 months | radiographic measurement using CBCT |
| soft tissue healing | 6 months | clinical measurement using landr et al index (healing index) in numerical |
| postoperative pain scores | 2 weeks | clinical measurement using VAS scale in numerical where No pain (0-4 mm) - mild pain (5-44 mm) -moderate pain (45-74 mm), and severe pain (75- 100 mm). |
Countries
Egypt
Outcome results
None listed