Cerebral Tumor
Conditions
Keywords
SPGB, ICP, CBF, AVDO2
Brief summary
This study aims to investigate the effect of Sphenopalatine Ganglion Block on ICP and arterio- jugular venous oxygen difference (AJVDO2) and jugular bulb oxygen saturation (SjVO2). Throughout this study, the efficacy of Sphenopalatine Ganglion Block as scalp block in craniotomy operation will be assessed, and the effect of SPGB on cerebral hemostasis during craniotomy will be evaluated by monitoring of both ICP, AJVDO2 and SjVO2.
Detailed description
This study was performed in the Neurosurgical operating room and included 52 patients allocated into two groups: the treatment group (block group) and the control group (non-block group). 26 patients enrolled in block group and 26 patients in non-block group. Intraoperative ICP monitoring by subdural ICP monitors will be done every 20 minutes in both block and non- block groups until craniotomy has been occurred, then at the time of closure of the dura . Arterio- jugular venous oxygen difference and Jugular venous bulb oxygen saturation changes will be recorded every 20 minutes in block and non- block groups throughout time of the surgery till closure of the dura.
Interventions
PROCEDURESPGB
Sphenopalatine Ganglion Block using 2% lidocaine in block group. Sphenopalatine Ganglion Block is performed by a hollow culture swab that is connected with a 21-gauge a syringe filled with three ml 2% lidocaine, inserted parallel to the floor of the nose until resistance is felt. The swab is at the posterior pharyngeal wall superior to the middle turbinate. The applicator was kept in the nostril for five to ten mins. The same procedure is done also in the second nostril SPGB using normal saline is performed in the control group
Sponsors
Zagazig University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Intervention model description
This study will be performed in the Neurosurgical operating room and included 52 patients allocated into two groups: the treatment group (block group) and the control group (non-block group). 26 patients enrolled in block group and 26 patients in non-block group. Intraoperative ICP monitoring by subdural ICP monitors will be done every 20 minutes in both block and non- block group. Jugular venous bulb oxygen saturation changes will be recorded every 20 minutes in block and non- block.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients who prepared for a neurosurgical intervention for elective supratentorial tumor removal * ASA 1 and 2 * Age above 18 years and below 65 years * Fully conscious patients.
Exclusion criteria
* Patients with cardiovascular and respiratory diseases * Pregnancy * Patient refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intracranial Pressure | Every 20 minutes until time of initial craniotomy, then again after the dura was sutured. | ICP changes checked by a subdural ICP monitor that positioned after the first burr hole at the opposite side of the tumor immediately after induction of anesthesia. ICP monitoring will be conducted every 20 minutes until time of initial craniotomy and at time of closure of the dura. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Jugular venous bulb oxygen saturation and cerebral arteriovenous oxygen content difference. | Every 20 minutes throughout the operation period. | Jugular venous bulb oxygen saturation will be measured then AVDO2 will be calculated. |
Countries
Egypt
Outcome results
None listed