Carpal Tunnel Syndrome
Conditions
Keywords
PRP injection, Local injection, CTS
Brief summary
Patients will be randomly divided into 3 equal groups: Group I received ultrasound guided injection of 2 mL PRP into the affected carpal tunnel. Group II received ultrasound guided injection of 2 mL steroids (40 mg triamcinolone acetonide). Group III received ultrasound guided injection of 2 mL saline as placebo control.
Detailed description
Patients will be randomly divided into 3 equal groups: Group I received ultrasound guided injection of 2 mL PRP into the affected carpal tunnel. Group II received ultrasound guided injection of 2 mL steroids (40 mg triamcinolone acetonide). Group III received ultrasound guided injection of 2 mL saline as placebo control. Each group will be injected twice with 2 weeks intervals. All procedures were done after informed consent. Evaluation of the patients at baseline, 3 and 6 months after last injection was done clinically by measuring visual analogue scale (VAS), electrophysiologically (by measuring motor and sensory nerve conduction studies of median nerve using a standardized technique) and ultrasonographic study by measuring cross sectional area (CSA) of median nerve at the level of pisiform.
Interventions
Platelet-rich plasma (PRP) promotes angiogenesis, neurogenesis, and nerve regeneration, also it could reduce swelling and inflammation of the flexor tenosynovitis.
DRUGTriamcinolone Acetonide
40 mg triamcinolone acetonide
DRUGSaline
Saline
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* mild or moderate idiopathic CTS (diagnosed clinically, ultrasonography & electrophysiologically and classified according to the American Association of neuromuscular diagnostic medicine monograph).
Exclusion criteria
* Patients with severe or secondary type of CTS
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| visual analogue scale | Change from 3 months after last injection and 6 months after last injection | Scale for assessement the degree of pain along 0-10 scale |
| measuring motor and sensory nerve conduction studies of median nerve using a standardized technique | Change from 3 months after last injection and 6 months after last injection | electrophysiologically by measuring motor and sensory nerve conduction studies of median nerve using a standardized technique |
| cross-sectional area (CSA) of the median nerve at the level of the pisiform. | Change from 3 months after last injection and 6 months after last injection | ultrasonographic study by measuring cross-sectional area (CSA) of the median nerve at the level of the pisiform. |
Countries
Egypt
Outcome results
None listed