Pregnancy
Conditions
Keywords
pregnancy, corneal biomechanical properties, intraocular pressure
Brief summary
It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child. The cornea consists of highly structured collagen fibers. Hence, it seams logically that corneal biomechanics also change during pregnancy.
Detailed description
It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child. The cornea consists of highly structured collagen fibers. Hence, it seams logically that corneal biomechanics also change during pregnancy. Measurement of intraocular pressure is highly dependant on corneal properties. With the Corvis ST device by Ocular Inc. it is possible to measure intraocular pressure and investigated corneal biomechanics. The aim of this study is therefore to compare corneal biomechanical properties during the third trimester with corneal biomechanical properties at 3 months after delivery.
Interventions
DEVICENon-Contact measurement of corneal properties
Corneal Properties will be measurement with the non-contact Corvis ST Air-Puff Tonometer by Oculus Inc.
Sponsors
University of Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 38 Years
Healthy volunteers
Yes
Inclusion criteria
* females * pregnant * age 18 to 38 yo * uncomplicated singleton pregnancy
Exclusion criteria
* any history of ocular disease or surgery other than conjunctivitis, especially no history of glaucoma or corneal disease * systemic diseases, i.e. diabetes, hypertension, collagenase * current contact lens wear * before pregnancy taking any systemic or ocular medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Deformation Amplitude | at 3 month post delivery compared to during third trimester | Change in Deformation Amplitude (in millimeters) at 3 month post delivery compared to during third trimester will be assessed. |
| Change in Applanation Length | at 3 month post delivery compared to during third trimester of the pregnancy | Change in Applanation Length (in millimeters) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. |
| Change in Corneal Velocity | at 3 month post delivery compared to during third trimester of the pregnancy | Change in Corneal Velocity (in meters/second) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. |
| Change in corneal thickness | at 3 month post delivery compared to during third trimester of the pregnancy | Change in corneal thickness (in millimeters) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. |
| Change in Intraocular pressure | at 3 month post delivery compared to during third trimester of the pregnancy | Change in intraocular pressure (in millimeters of mercury, mmHg) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. |
Countries
Switzerland
Contacts
Primary ContactMarc o Toeteberg-Harms, MD, FEBO
Backup ContactBelgin o Özsoy, MD
Outcome results
None listed