Cardiac Surgery
Conditions
Brief summary
To observe the effect of RIPC on the function of vital organs after cardiac surgery, and to explore its possible mechanism.
Interventions
DEVICERIPC
The tourniquet attached to the upper limb was inflated and blocked for 5 minutes, then deflated for 5 minutes to restore blood flow and induce ischemic preconditioning.
Sponsors
Shanghai Zhongshan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients with aortic valve, mitral valve, tricuspid valve, ascending aortic disease and coronary atherosclerosis who were admitted to hospital for elective valve repair, replacement, artificial vascular replacement or coronary artery bypass grafting. * age 18-80 years old. * No restriction on gender. * ASA grade II\ III. * NYHAII\ III level. * the patient or his family member has signed the informed consent form for the clinical trial
Exclusion criteria
* those who are disabled in the selected test. * less than 5 years of education. * The preoperative left ventricular ejection fraction ((LVEF)) was less than 40%. * Myocardial infarction occurred in nearly one month. * malignant tumor, hematological disease, severe liver and kidney dysfunction, recent severe infection, etc. * History of nervous system, immune system and mental illness. * recent operation history of heart, brain, lung, liver, kidney and other important organs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of acute renal injury after operation | within 7 days after operation | According to the (KDIGO) guidelines for improving the prognosis of renal disease |
| The incidence of postoperative delirium | within 7 days after operation | CAM score greater than 22 |
Countries
China
Outcome results
None listed