Hypertension and Controlled Hypotension in the Elderly

Effect of Preoperative Hypertension and Controlled Hypotension on Postoperative Delirium in the Elderly

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04433416

Enrollment

Registered

2020-06-16

Start date

2020-06-14

Completion date

2020-12-07

Last updated

2021-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium

Brief summary

Comparision of Exposed Factors of Preoperative Hypertension and Intraoperative Controlled Hypotension on Postoperative Delirium in the Elderly under Radical Resection of Head, Neck and Maxillofacial Tumor

Detailed description

Postoperative delirium has a higher incidence in elderly patients after general anesthesia，and It is closely related to the type of surgery, the length of surgery, and the patient's physique.Because head and neck maxillofacial radical surgery requires free flap transplantation and longer duration,and hemorrhage is more when the primary focus is removed，Intraoperative blood pressure reduction is needed to reduce bleeding，therefore, hypoperfusion of craniocerebral blood flow will occur.Low cerebral perfusion is closely related to the occurrence of postoperative delirium.Patients undergoing this type of surgery have more preoperative complications，hypertension is particularly common.Therefore, this study mainly studied the correlation between the preoperative blood pressure level and the controlled hypotension level in patients with radical head and neck and maxillofacial tumors and the incidence of postoperative delirium.

Interventions

DIAGNOSTIC_TESThypertension

If the patient has two or more blood pressure values ≥140/90mmHg in a calm state, he is included in this group

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patients who underwent radical anesthesia for oral and maxillofacial malignant tumors in our hospital 2. ASA grade is Ⅰ-Ⅱ 3. Patient is older than 60 years

Exclusion criteria

1. The patient has mental and mental disorders (eg schizophrenia, Alzheimer's disease) 2. There was severe anemia before operation (Hb\<80g/L) 3. Patients had cerebral vascular complications such as cerebral infarction and lacunar infarction before operation 4. Patients who do not cooperate with this trial 5. Long-term use of sedative drugs or analgesics

Design outcomes

Primary

Measure	Time frame	Description
Degree of delirium	up to three days after surgery	From the first to the third day after surgery, the patient will be evaluated for delirium using the CAM scale.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026