Pathogenic Microorganisms in Adult Severe Pneumonia Patients

A Multicenter Clinical Study on the Detection of Pathogenic Microorganisms in Adult Severe Pneumonia Patients in Liaoning Province

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04433403

Enrollment

300

Registered

2020-06-16

Start date

2020-07-01

Completion date

2024-06-30

Last updated

2021-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pathogenic Microorganism of Serious Pneumonia

Brief summary

This study aimed to evaluate pathogenic microorganisms in adult severe pneumonia patients in different cities of Liaoning Province

Detailed description

The pathogenic microorganisms of adult patients with severe pneumonia is detected in this study. Clinical treatment does not involve , so it meets the ethical requirements. The clinical data, laboratory test results and imaging data of adult severe pneumonia patients in different hospitals in different cities are recorded. The pathogenic microorganism is detected by second-generation sequencing of lower respiratory tract sputum or alveolar lavage fluid samples, and the data were sorted out to draw the pathogenic microorganism spectrum of adult severe pneumonia in Liaoning area. It will be used to guide clinical empirical treatment.

Interventions

OTHERpathogenic microorganism

Detection of pathogenic microorganisms in adult severe pneumonia by second generation sequencing

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Meet the standard of severe pneumonia： Main standards： Requiring mechanical ventilation or septic shock requiring vasoconstrictor therapy. Secondary standards：(only if 3 items are met) Disturbance of consciousness; respiratory rate ≥ 30 times/min; PaO2/FiO2 ≤ 250, or PaO2 \< 60mmHg; azotemia (BUN ≥ 7.12mmol / L); hypotension requires strong fluid resuscitation; infiltration of multiple lobes; leucopenia (WBC \< 4 × 109 / L); thrombocytopenia (\< 10 × 109 / L); hypothermia (T \< 36 ℃).

Exclusion criteria

* refuse to sign informed consent; inaccurate results due to unqualified sputum or BALF samples

Design outcomes

Primary

Measure	Time frame	Description
Pathogenic microorganism spectrum of adult severe pneumonia in Liaoning Province	2020.7-2023.12	Detection of pathogenic microorganisms in severe pneumonia by second generation sequencing

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026