Back Pain - Linking Phenotype to Pain Mechanism and Outcome.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04433299

Enrollment

150

Registered

2020-06-16

Start date

2019-11-01

Completion date

2025-06-03

Last updated

2026-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low Back Pain

Keywords

low back pain, phenotype

Brief summary

To investigate whether different clinical, psychophysical and neurophysiological phenotypes can be identified among low back pain patients

Detailed description

Low back pain patients will fill in a detailed questionnaire (incl. pain drawing) about their pain. Some of them will undergo a standardized quantitative sensory testing protocol and an fMRI procedure.

Interventions

OTHERno intervention, observational

no intervention, observational

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

-primary complaint: low back pain clinically not attributable to red flags

Exclusion criteria

* any major medical or psychiatric condition that affects pain sensitivity * contraindications to MRI

Design outcomes

Primary

Measure	Time frame	Description
spatial pain extent	baseline	spatial pain extent (body map)
measures for central sensitization	baseline	temporal summation and conditioned pain modulation

Secondary

Measure	Time frame	Description
changes in spatial pain extent	changes from baseline to 3 months	changes in spatial pain extent (bodymap)
changes in measures for central sensitization	changes from baseline to 3 months	changes in temporal summation and conditioned pain modulation

Countries

Switzerland

Contacts

PRINCIPAL_INVESTIGATORPetra Schweinhardt, MD, PhD

Balgrist University Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 28, 2026