Opioid-use Disorder
Conditions
Keywords
Transcranial magnetic stimulation, Reward processing, Cognitive control
Brief summary
The primary aims of this study are to identify impaired cognitive control in opioid use disorder (OUD) and subsequently to examine the effects of transcranial magnetic stimulation (TMS) on reward processing, as measured by the reward positivity (an electrophysiological signal) in people with OUD. To this end, the investigators will adopt a randomized sham-controlled trial to evaluate the efficacy of Ri-TMS on cognitive control in OUD. The investigators hypothesize that Ri-TMS will be successful in modulating the reward positivity in opioid users in the active TMS condition.
Detailed description
The design is primarily a randomized control-trial design, comparing the effects of placebo (sham) and active TMS stimulation on reward processing across two groups of participants - healthy controls and opioid users. Participants will be asked to engage in a virtual T-maze task, a reward-based choice task that elicits robust reward positivities. During this task participants will receive simultaneous EEG/TMS, while they engage in the virtual T-maze decision making task, used in our previous reward positivity studies on SUDs. ERPs will be recorded throughout the T-Maze task, and the reward positivity will be measured as the difference in maximum amplitude between reward and no-reward feedback conditions. The TMS coil will be positioned using a an Adept Viper s850 robotic arm (SmartMove, ANT Neuro, Enschede, The Netherlands), providing precise targeting of the predetermined left dorsolateral prefrontal (DLPFC) coordinate (\< 10 mm from the scalp, orientated at a 45º angle). Participants in the active TMS condition will receive rTMS pulses throughout the duration of the T-Maze task, with a maximum of 2000 pulses delivered to each participant. Identical parameters will be applied to the SHAM group with the exception that the TMS coil will be flipped 180º to mimic auditory stimulation.
Interventions
rTMS will be used to stimulate neuronal activity of the dorsolateral prefrontal cortex (DLPFC). Participants will receive no more than 2000 pulses of rTMS at 110% of participants' resting motor threshold at 10 Hz continuously for the duration of the t-maze task.
Sham TMS will be used to mimic the auditory sensation of the Active rTMS condition. Protocols for the sham condition will be the same as the active condition, however the TMS coil will be flipped 180 degrees so that participants in this condition will not receive any active stimulation.
Sponsors
Rutgers University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
Participants will be blinded as to TMS condition (active or sham)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Native English speakers * Males and Females aged 18-55 years old * Ability to provide informed written or verbal consent * Opioid dependent individuals (according to the Alcohol, Smoking and Substance Involvement Screening Test opioid dependence score), or * Healthy controls with no history of significant substance use
Exclusion criteria
* Un-correctable visual impairment * Uninterruptable central nervous system medication * TMS contraindications (e.g., pregnancy, braces, history of seizures, metal implants). * History of neurological or psychiatric illness * Diagnosed learning disability * History of significant head injury (loss of consciousness for more than five minutes) * Substance abuse (Participants who score above 39.5 on the Global Continuum of Substance Risk scale of the Alcohol, Smoking and Substance Involvement Screening Test - controls only) * Use of psychoactive or vasoactive medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reward Positivity | Day 0 (day of testing) | The reward positivity is an event-related brain potential, sensitive to reward feedback. The reward positivity will be measured during the t-maze task, where participants will receive feedback on choices (Reward, No-reward). Reward positivity amplitude will be determined by identifying the maximum absolute amplitude of the difference wave within a 200- to 400-ms window following feedback onset. The reward positivity will be evaluated along front-central electrodes (Fz, FCz, Cz). |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Active TMS - OUD Opioid Use Disorder (OUD) Participants in the active condition will receive repetitive TMS (rTMS), delivered at 110% of participants' resting motor threshold at 10 Hz continuously over the predefined DLFPC target for a total of 2000 pulses
Active repetitive transcranial magnetic stimulation (rTMS): rTMS will be used to stimulate neuronal activity of the dorsolateral prefrontal cortex (DLPFC). Participants will receive no more than 2000 pulses of rTMS at 110% of participants' resting motor threshold at 10 Hz continuously for the duration of the t-maze task. | 16 |
| Sham TMS - OUD Identical parameters will be applied to the Opioid Use Disorder (OUD) SHAM group with the exception that the TMS coil will be flipped 180º to mimic auditory stimulation
Sham repetitive transcranial magnetic stimulation (rTMS): Sham TMS will be used to mimic the auditory sensation of the Active rTMS condition. Protocols for the sham condition will be the same as the active condition, however the TMS coil will be flipped 180 degrees so that participants in this condition will not receive any active stimulation. | 18 |
| Active TMS - HC Healthy Control (HC) Participants in the active condition will receive repetitive TMS (rTMS), delivered at 110% of participants' resting motor threshold at 10 Hz continuously over the predefined DLFPC target for a total of 2000 pulses
Active repetitive transcranial magnetic stimulation (rTMS): rTMS will be used to stimulate neuronal activity of the dorsolateral prefrontal cortex (DLPFC). Participants will receive no more than 2000 pulses of rTMS at 110% of participants' resting motor threshold at 10 Hz continuously for the duration of the t-maze task. | 22 |
| Sham TMS - HC Identical parameters will be applied to the Healthy Control (HC) SHAM group with the exception that the TMS coil will be flipped 180º to mimic auditory stimulation
Sham repetitive transcranial magnetic stimulation (rTMS): Sham TMS will be used to mimic the auditory sensation of the Active rTMS condition. Protocols for the sham condition will be the same as the active condition, however the TMS coil will be flipped 180 degrees so that participants in this condition will not receive any active stimulation. | 25 |
| Total | 81 |
Baseline characteristics
| Characteristic | Sham TMS - OUD | Active TMS - HC | Sham TMS - HC | Active TMS - OUD | Total |
|---|---|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical Between 18 and 65 years | 18 Participants | 22 Participants | 25 Participants | 16 Participants | 81 Participants |
| Age, Continuous | 46 years STANDARD_DEVIATION 19 | 36 years STANDARD_DEVIATION 12 | 34 years STANDARD_DEVIATION 11 | 42 years STANDARD_DEVIATION 9 | 39 years STANDARD_DEVIATION 11 |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants | 2 Participants | 2 Participants | 1 Participants | 5 Participants |
| Race (NIH/OMB) Black or African American | 12 Participants | 10 Participants | 8 Participants | 10 Participants | 40 Participants |
| Race (NIH/OMB) More than one race | 0 Participants | 3 Participants | 4 Participants | 1 Participants | 8 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) White | 6 Participants | 7 Participants | 11 Participants | 4 Participants | 28 Participants |
| Region of Enrollment United States | 18 μV (Microvolts | 22 μV (Microvolts | 25 μV (Microvolts | 16 μV (Microvolts | 81 μV (Microvolts |
| Sex: Female, Male Female | 6 Participants | 10 Participants | 12 Participants | 5 Participants | 33 Participants |
| Sex: Female, Male Male | 12 Participants | 12 Participants | 13 Participants | 11 Participants | 48 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk |
|---|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 16 | 0 / 18 | 0 / 22 | 0 / 25 |
| other Total, other adverse events | 0 / 16 | 0 / 18 | 0 / 22 | 0 / 25 |
| serious Total, serious adverse events | 0 / 16 | 0 / 18 | 0 / 22 | 0 / 25 |
Outcome results
Primary
Reward Positivity
The reward positivity is an event-related brain potential, sensitive to reward feedback. The reward positivity will be measured during the t-maze task, where participants will receive feedback on choices (Reward, No-reward). Reward positivity amplitude will be determined by identifying the maximum absolute amplitude of the difference wave within a 200- to 400-ms window following feedback onset. The reward positivity will be evaluated along front-central electrodes (Fz, FCz, Cz).
Time frame: Day 0 (day of testing)
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Active TMS - OUD | Reward Positivity | -5.2 μV (microvolts) | Standard Deviation 2 |
| Sham TMS - OUD | Reward Positivity | -2.3 μV (microvolts) | Standard Deviation 3 |
| Active TMS - Controls | Reward Positivity | -4.4 μV (microvolts) | Standard Deviation 3 |
| Sham TMS - Controls | Reward Positivity | -4.6 μV (microvolts) | Standard Deviation 3 |