Anesthesia, Nociceptive Pain
Conditions
Keywords
General anesthesia, Nociceptive Pain, Monitoring, Pediatric anesthesia
Brief summary
Description of the standard values and fluctuations of the new NIPE index during routine pediatric anesthesia. NIPE monitor connected to anesthesia monitor, displays an instantaneous value ranging from 0 to 100. NIPE values described at different time points during anesthesia: beginning of induction, intubation, extubation, skin incision, opioid administration, vasopressors or atropine administration, transfusion, volume expansion. In addition, NIPE values during hemodynamic events (heart rate or blood pressure increase greater than 20%) will be recorded.
Interventions
PROCEDURENIPE (Newborn Infant Parasympathetic Evaluation) monitoring
Non invasive monitor connected to standard anesthesia monitor (no part of the device in contact with the patient) during anesthesia.
Sponsors
Fondation Apicil
University Hospital, Lille
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 15 Years
Healthy volunteers
No
Inclusion criteria
* Surgery under general anesthesia * Absence of analgesic treatment in the 24 hours before the intervention
Exclusion criteria
* Central or peripheral neuropathy * Non sinus arrythmia, pace maker * Cardiac surgery * Analgesic medication within 24 hours before surgery * Anti cholinergic or anti arrythmic chronic medication * Opposition of the legal tutor or of the child
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variation of the instantaneous NIPE index after opioid administration | 5 minutes after opioid administration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the area under the ROC curve of NIPE value | Baseline and 5 minutes before the first hemodynamic event. | the NIPE value is definied by the predictibility of a hemodynamic event : 20% increase in Baseline heart rate, blood pressure and NIPE values recorded just before skin incision |
| Variation of the instantaneous NIPE index after skin incision | 5 minutes after skin incision | — |
| Variation of the instantaneous NIPE index after insertion of airway control device | 5 minutes after insertion of airway control device | — |
| Variation of the instantaneous NIPE index after removal of airway control device | 5 minutes after removal of airway control device | — |
| Variation of the instantaneous NIPE index after anesthetic induction | 5 minutes after anesthetic induction | — |
Countries
France
Outcome results
None listed