Aging
Conditions
Brief summary
This study evaluates the effects of six-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in men and women aged 70 years and over.
Interventions
DIETARY_SUPPLEMENTHydrogen-rich water
A tablet that produces hydrogen dissolved in a glass of water
OTHERControl Water
A glass of tap water
Sponsors
University of Novi Sad, Faculty of Sport and Physical Education
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age \> 70 years * Free of acute disorders
Exclusion criteria
* History of dietary supplement use during the past 4 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in TeloTAGGG Telomerase PCR activity in serum | Baseline vs. 6 months post-intervention | Baseline vs. 6 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in blood concentration of advanced glycation end product | Baseline vs. 6 months post-intervention | Baseline vs. 6 months |
| Change in lipid peroxidation | Baseline vs. 6 months post-intervention | Baseline vs. 6 months |
| Change in serum FGF21 | Baseline vs. 6 months post-intervention | Baseline vs. 6 months |
| Change in DNA methylation | Baseline vs. 6 months post-intervention | Baseline vs. 6 months |
| Change in ADAS-Cog score (0-70 scale, higher scores indicating greater cognitive impairment) | Baseline vs. 6 months post-intervention | Baseline vs. 6 months |
| Change in facial wrinkling (0-100 scale; higher scores mean worse outcome) | Baseline vs. 6 months post-intervention | Baseline vs. 6 months |
| Change in maximal oxygen uptake estimated by step-in-place test | Baseline vs. 6 months post-intervention | Baseline vs. 6 months |
| Change in serum TET2 | Baseline vs. 6 months post-intervention | Baseline vs. 6 months |
Countries
Serbia
Outcome results
None listed