Non-surgical Periodontal Treatment, Periodontitis, Smoking
Conditions
Brief summary
This study aimed to investigate the effect of smoking and non-surgical periodontal treatment on gingival crevicular fluid CyPA and EMMPRIN levels in patients with periodontitis. Twenty-eight patients with periodontitis (14 non-smoker and 14 smoker) and 30 control subjects (15 non-smoker and 15 smoker) were included into the study. Non-surgical periodontal treatment was applied to all periodontitis patients. Periodontal parameters and GCF CyPA and EMMPRIN levels were evaluated during 3 months following non-surgical periodontal treatment. GCF CyPA and EMMPRIN levels were analyzed by ELISA.
Interventions
PROCEDUREnon-surgical periodontal treatment
Non-surgical periodontal treatment program was as following: First, motivation and oral hygiene instructions were given to all participants with periodontitis. The modified-Bass tooth brushing technique with a given dentifrice and toothbrush twice a day, and dental flossing/ interdental brushing once a day was advised to all patients with periodontitis. Second, scaling using an ultrasonic device and root planning by hand instruments under local anesthesia was performed.
Sponsors
Ege University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
29 Years to 61 Years
Healthy volunteers
Yes
Inclusion criteria
* generalized periodontitis with stage III-IV & Grade B * no systemic and periodontal diseases * smokers (minimum 10 cigarettes per day for at least ten years) * non-smokers (never smoked)
Exclusion criteria
* Systemic diseases * Infectious diseases * Pregnancy or lactating * Having periodontal treatment during the last 6 months * Having antibiotic treatment within the past 3 months * Former smokers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in gingival crevicular fluid CypA total amounts | Baseline, 1 week, 1., 3. months | GCF CyPA levels were analyzed by ELISA |
| Change in gingival crevicular fluid EMMPRIN total amounts | Baseline, 1 week, 1., 3. months | GCF EMMPRIN levels were analyzed by ELISA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in probing depth | Baseline, 1., 3. months | Probing depth was measured with Williams periodontal probe. |
| Change in bleeding on probing | Baseline, 1., 3. months | Bleeding on probing was evaluated the presence or absense following bleeding upon probing. |
Outcome results
None listed