Kidney Stone
Conditions
Keywords
kidney stone, oxalate
Brief summary
This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies. Subjects will then be administered an intravenous (IV) load of glycolate, providing additional blood and urine samples afterwards to measure any increase in oxalate levels.
Interventions
OTHERControlled Diet
Participants will consume a controlled low oxalate diet for five days.
OTHERGlycolate Administration
Participants will come to the UAB Clinical Research Unit (CRU) and be administered a glycolate load via intravenous (IV) catheter.
Sponsors
University of Alabama at Birmingham
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* at least 18 years of age * history of calcium oxalate stones * heterozygous mutation of the AGXT gene, as evidenced by results from the Invitae Nephrolithiasis Panel * willingness to comply with a controlled diet for five days
Exclusion criteria
* pregnant individuals * individuals who are currently breast feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urinary Oxalate Excretion | Baseline through Day 6 | Urinary oxalate excretion from urine samples will be measured as mg/day |
Contacts
Primary ContactDemond Wiley
Outcome results
None listed