Kidney Stone, Urolithiasis, Calcium Oxalate
Conditions
Keywords
kidney stone, oxalate
Brief summary
This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies.
Interventions
OTHERControlled Diet
Participants will consume a controlled low oxalate diet for five days.
Sponsors
University of Alabama at Birmingham
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* at least 18 years of age * history of calcium oxalate stones * heterozygous mutation of the AGXT gene, as evidenced by results from the Invitae Nephrolithiasis Panel * willingness to comply with a controlled diet for five days
Exclusion criteria
* pregnant individuals * individuals who are currently breast feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urinary Oxalate Excretion | Baseline through Day 4 | Urinary oxalate excretion from urine samples will be measured as mg/day |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORKyle Wood, MD
University of Alabama at Birmingham
Outcome results
None listed