Schizophrenia
Conditions
Keywords
Schizophrenia, mind body intervention ,Baduanjin
Brief summary
As an ancient, popular Chinese exercise, Baduanjin is characterized by symmetrical posture, deep breathing and meditation and easy to learn. Previous studies showed immediate effect of Baduanjin on cognition in patients with schizophrenia.The purpose of this study is to investigate the immediate effect and chronic effect of Baduanjin exercise on physical fitness, cognition and daily functions in middle-aged and older adults with schizophrenia.
Detailed description
A single-blind, 2-arm randomized controlled trial investigating the benefits of Baduanjin exercise on middle-aged and older patients with schizophrenia. A total of 48 participants will be assigned to either 12 weeks of 60-minute two sessions per week Baduanjin exercise group or a brisk walking group. Primary outcomes are physical fitness and cognition functions. Secondary outcomes are dual task performance and daily functions. Evaluation will be completed at baseline, immediately after treatment and 4-week follow up.
Interventions
BEHAVIORALBaduanjin exercise program
The sessions includes 10-minute warm-up, 40-minute Baduanjin exercise and 10-minute cool down.
BEHAVIORALBrisk walking program
The sessions includes 10-minute warm-up, 40-minute brisk walking and 10-minute cool down.
Sponsors
National Taiwan University
Chang Gung Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Having a diagnosis of schizophrenia according to the DSM-5. * Independent adult aged 40 years or older in the day-care center. * Having a stable mental status without shift in medication and keep in same dose for at least one month.
Exclusion criteria
* Serious physical conditions that will impede participation, such as cardiovascular disease, musculoskeletal disease or pulmonary system disease. * Visual or auditory impairment that precludes completion of assessment. * Acute psychosis requiring hospitalization. * Presence of severe withdrawal or profound cognitive disability that cause difficulties in following instructions. * Participating in another clinical trial at the same time.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change scores of Logical Memory | Baseline, immediate after treatment, 4-week follow up | It is a subtest of the Wechsler Memory Scale. This test evaluates memory. |
| Change scores of Timed up-and-go test | Baseline, immediate after treatment, 4-week follow up | This test evaluates functional mobility, agility and balance |
| Change scores of Montreal cognitive assessment | Baseline, immediate after treatment, 4-week follow up | This test evaluates global cognition. |
| Change scores of Trail making test (part A and part B) | Baseline, immediate after treatment, 4-week follow up | This test evaluates speed of processing, visual attention and cognitive flexibility. |
| Change scores of 6-minute walk test | Baseline, immediate after treatment, 4-week follow up | This test evaluates cardiovascular fitness and walking speed. |
| Change scores of 30-second chair stand test | Baseline, immediate after treatment, 4-week follow up | This test evaluates muscular endurance of lower-extremities. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change scores of dual task Timed up-and-go test (cognitive) | Baseline, immediate after treatment, 4-week follow up | This test combine serial three counting and Timed up-and-go test simultaneously. It evaluates dual task performance. |
| Change scores of Activities of Daily Living Rating Scale III | Baseline, immediate after treatment, 4-week follow up | It is a self-administered, paper-and-pencil test that evaluates daily functions |
| Change scores of dual task Timed up-and-go test (manual) | Baseline, immediate after treatment, 4-week follow up | This test requires carry a cup of water 3 cm from the top of the cup while performing the Timed up-and-go test. It evaluates dual task performance. |
Countries
Taiwan
Outcome results
None listed